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Nowadays, nucleic acid therapy has become a promising way for the treatment of various malignant diseases. Cyclodextrin (CD)-based nucleic acid delivery systems have attracted widespread attention due to the favorable chemical structures and excellent biological properties of CD. Recently, a variety of CD-based nucleic acid delivery systems has been designed according to the different functions of CD for flexible gene therapies. In this review, the construction strategies and biomedical applications of CD-based nucleic acid delivery systems are mainly focused on. The review begins with an introduction to the synthesis and properties of simple CD-grafted polycations. Thereafter, CD-related supramolecular assemblies based on different guest components are discussed in detail. Finally, different CD-based organic/inorganic nanohybrids and their relevant functions are demonstrated. It is hoped that this brief review will motivate the delicate design of CD-based nucleic acid delivery systems for potential clinical applications. © 2020 Wiley-VCH GmbH.

Citation

Chen Xu, Bingran Yu, Yu Qi, Nana Zhao, Fu-Jian Xu. Versatile Types of Cyclodextrin-Based Nucleic Acid Delivery Systems. Advanced healthcare materials. 2021 Jan;10(1):e2001183

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PMID: 32935932

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