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Autophagy and cap-dependent mRNA translation are tightly regulated by the mechanistic target of rapamycin complex 1 (mTORC1) signalling complex in response to nutrient availability. However, the regulation of these processes, and mTORC1 itself, is different during mitosis, and this has remained an area of significant controversy; for example, studies have argued that autophagy is either repressed or highly active during mitosis. Recent studies have shown that autophagy initiation is repressed, and cap-dependent mRNA translation is maintained during mitosis despite mTORC1 activity being repressed. This is achieved in large part by a switch from mTORC1- to cyclin-dependent kinase 1 (CDK1)-mediated regulation. Here, we review the history and recent advances and seek to present a unifying model to inform the future study of autophagy and mTORC1 during mitosis. Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

Citation

Richard I Odle, Oliver Florey, Nicholas T Ktistakis, Simon J Cook. CDK1, the Other 'Master Regulator' of Autophagy. Trends in cell biology. 2021 Feb;31(2):95-107

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PMID: 33272830

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