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Influenza virus can trigger atypical hemolytic uremic syndrome and present with complement-driven thrombotic microangiopathy (TMA). When administered promptly, complement-blocking therapies can spare organ injury and be lifesaving. However, diagnosing TMA in the setting of a severe viral infection can be challenging, as a significant overlap of symptoms and disease complications exists. This is particularly true in influenza virus infections and more recently, Coronavirus disease 2019 (COVID-19) infections. We present a 16-year-old male with H1N1 influenza-induced atypical hemolytic uremic syndrome who quickly improved with complement-blocking therapy, highlighting an urgent need to include TMA in the differential diagnosis of severe viral infections. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.

Citation

Anthony Sabulski, Edward J Nehus, Sonata Jodele, Kiersten Ricci. Diagnostic Considerations in H1N1 Influenza-induced Thrombotic Microangiopathy. Journal of pediatric hematology/oncology. 2022 Jan 01;44(1):e237-e240

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PMID: 33369997

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