Synthesis and antibacterial evaluation of new monobactams.

Monobactams play an important role in antibiotic drug discovery. Based on the structural characteristics of aztreonam and its biological targets, six new monobactam derivatives (2a-c and 3a-c) were synthesized and their in vitro antibacterial activities were investigated. Compounds 2a-c showed higher activities against tested gram-negative bacteria than that of parent aztreonam. Monobactam 2c exhibited the most potent activities, with MIC ranging from 0.25 to 2 μg/mL against most bacteria. Copyright © 2021. Published by Elsevier Ltd.

Citation

Zaw Min Thu, Jian Sun, Jingwen Ji, Lili He, Jinbo Ji, Zafar Iqbal, Ko Ko Myo, Yuanyu Gao, Lijuan Zhai, Yangxiu Mu, Dong Tang, Giovanni Vidari, Haikang Yang, Zhixiang Yang. Synthesis and antibacterial evaluation of new monobactams. Bioorganic & medicinal chemistry letters. 2021 May 01;39:127878

Mesh Tags

Substances

PMID: 33636305

search → result