Correlation Engine 2.0
Clear Search sequence regions


Sizes of these terms reflect their relevance to your search.

Although excessive fat and caffeine intake are independent risk factors for bone microstructural and functional disturbances, their association remains overlooked. Thus, we investigated the impact of high-fat diet (HFD) and caffeine alone and combined on serum lipid profile, bone microstructure, micromineral distribution and biomechanical properties. Forty female C57BL/6 mice were randomized into 4 groups daily treated for seventeen weeks with standard diet (SD) or HFD (cafeteria diet) alone or combined with 50 mg/kg caffeine. The association between HFD and caffeine reduced the weight gain compared to animals receiving HFD alone. Caffeine alone or combined with HFD increases total and HDL cholesterol circulating levels. HFD also reduced calcium, phosphorus and magnesium bone levels compared to the groups receiving SD, and this reduction was aggravated by caffeine coadministration. From biomechanical assays, HFD combined with caffeine increased bending strength and stiffness of tibia, a finding aligned with the marked microstructural remodeling of the cortical and cancellous bone in animals receiving this combination. Our findings indicated that HFD and caffeine interact to induce metabolic changes and bone microstructural remodeling, which are potentially related to bone biomechanical adaptations in response to HFD and caffeine coadministration. Copyright © 2021 Elsevier Inc. All rights reserved.

Citation

Fernanda Batista de Souza, Rômulo Dias Novaes, Cynthia Fernandes Ferreira Santos, Franciele Angelo de Deus, Felipe Couto Santos, Luiz Carlos Maia Ladeira, Reggiani Vilela Gonçalves, Daniel Silva Sena Bastos, Ana Cláudia Ferreira Souza, Mariana Machado-Neves, Eliziária Cardoso Dos Santos. High-fat diet and caffeine interact to modulate bone microstructure and biomechanics in mice. Life sciences. 2021 Jul 01;276:119450

Expand section icon Mesh Tags

Expand section icon Substances


PMID: 33798548

View Full Text