Correlation Engine 2.0
Clear Search sequence regions


  • adult (1)
  • blood (1)
  • case control studies (1)
  • cases (2)
  • cytokines (4)
  • diagnosed (2)
  • female (1)
  • humans (1)
  • IFN γ (2)
  • il 11 (1)
  • IL 1β (2)
  • IL 2 (1)
  • IL 6 (2)
  • IL 8 (2)
  • il10 (1)
  • il11 (1)
  • il12 (2)
  • il2 (1)
  • il4 (1)
  • il6 (1)
  • il8 (1)
  • patients (6)
  • plasma (1)
  • polycythemia vera (8)
  • risk factors (1)
  • thrombosis (3)
  • tnf α (1)
  • Sizes of these terms reflect their relevance to your search.

    Thrombo-hemorrhagic complications cause significant morbidity and mortality in patients with polycythemia vera (PV). To assay and correlate inflammatory cytokines with the thrombotic risk in PV patients. This prospective observational study was carried out at Postgraduate Institute of Medical Education and Research, Chandigarh, India over 18-months. The study enrolled 52 patients with PV (newly diagnosed = 28, follow-up = 24), and 20 age/sex-matched controls. Cytokine analysis for IL 1β, IL2, IL4, IL6, IL8, IL10, IL11, IL12/23p40, TNFα, and IFN-γ was performed on the peripheral blood (before treatment initiation for newly diagnosed cases, and after 7 days of stopping drugs for follow-up cases) by flow cytometry-based cytokine bead analysis (CBA) using CBA kits (BD™ biosciences, USA). Results were analyzed using SPSS Statistics 22.0. The mean age of patients was 51.9 ± 13 years. Levels of IL-6, IL-1β, IL-8, IL-11, IL-12/23p40 were significantly raised, however, TNF-α, and IFN-γ levels were significantly lower in the PV population as compared to controls. A significant correlation between the levels of IL-6, IL-2, and IL-8 with the overall risk of thrombosis in PV patients was observed. PV patients display an aberrant pattern of plasma cytokine expression, the levels of which correlate with the thrombotic risk. Copyright © 2021 Elsevier Inc. All rights reserved.

    Citation

    Ankur Jain, Prateek Deo, Man Updesh Singh Sachdeva, Parveen Bose, Deepesh Lad, Gaurav Prakash, Alka Khadwal, Neelam Varma, Subhash Varma, Pankaj Malhotra. Aberrant expression of cytokines in polycythemia vera correlate with the risk of thrombosis. Blood cells, molecules & diseases. 2021 Jul;89:102565

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 33831662

    View Full Text