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    A PDMS (Polydimethylsiloxane) microfluidic channel coupled with UV-vis fibre-optic spectrometer and new synthesized colorimetric probe was integrated into an optofluidic based Lab-on-a-chip device for highly sensitive and real-time quantitative measurements of fluoride ions (F¯). An 'S' shaped microchannel in a microfluidic device was designed to act as microreactor to facilitate the continuous reaction between synthetized colorimetric probe (sensor) and ions. Following this reaction, the UV-vis optical probe in the downstream detection zone of the microfluidic device was used to capture their spectrum and present as concentration in real-time conditions. An initial study of the developed colorimetric probe with multi-colour change with several binding and chromophore groups such as -OH, -NH and -NO2 groups confirmed its high sensitivity and selectivity for ions with a detection limit of 0.79 ppm. The performance of the developed optofluidic device was evaluated for the selective, sensitive detection of ions including real samples out-performing conventional methods. The technology has advantages such as low sample consumption, rapid analysis, high sensitivity and portability. Presented new Lab-on-a-chip device provides many competitive advantages for the real-time analysis of ions needed across broad sectors. Copyright © 2021 Elsevier B.V. All rights reserved.

    Citation

    Mahesh P Bhat, Mahaveer Kurkuri, Dusan Losic, Madhuprasad Kigga, Tariq Altalhi. New optofluidic based lab-on-a-chip device for the real-time fluoride analysis. Analytica chimica acta. 2021 May 15;1159:338439

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    PMID: 33867030

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