Correlation Engine 2.0
Clear Search sequence regions


  • cellular (3)
  • cellular processes (1)
  • cricetulus (1)
  • hamster (9)
  • host cell (1)
  • humans (1)
  • ovary (9)
  • past (1)
  • research (2)
  • Sizes of these terms reflect their relevance to your search.

    Chinese hamster ovary (CHO) cells are one of the most commonly used host cell lines used for the production human therapeutic proteins. Much research over the past two decades has focussed on improving the growth, titre and cell specific productivity of CHO cells and in turn lowering the costs associated with production of recombinant proteins. CHO cell engineering has become of particular interest in recent years following the publication of the CHO cell genome and the availability of data relating to the proteome, transcriptome and metabolome of CHO cells. However, data relating to the cellular post-translational modification (PTMs) which can affect the functionality of CHO cellular proteins has only begun to be presented in recent years. PTMs are important to many cellular processes and can further alter proteins by increasing the complexity of proteins and their interactions. In this review, we describe the research presented from CHO cells to date related on three of the most important PTMs; glycosylation, phosphorylation and ubiquitination. Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

    Citation

    Laura Bryan, Martin Clynes, Paula Meleady. The emerging role of cellular post-translational modifications in modulating growth and productivity of recombinant Chinese hamster ovary cells. Biotechnology advances. 2021 Jul-Aug;49:107757

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 33895332

    View Full Text