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    A novel method for the synthesis of N-difluoromethyl-2-pyridones was described. This protocol enables the synthesis of N-difluoromethyl-2-pyridones from readily available pyridines using mild reaction conditions that are compatible with a wide range of functional groups. The preliminary mechanistic study revealed that N-difluoromethylpyridinium salts were the key intermediates to complete this conversion.

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    Sen Zhou, Xiaoya Hou, Kai Yang, Minjie Guo, Wentao Zhao, Xiangyang Tang, Guangwei Wang. Direct Synthesis of N-Difluoromethyl-2-pyridones from Pyridines. The Journal of organic chemistry. 2021 May 07;86(9):6879-6887

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    PMID: 33905251

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