Correlation Engine 2.0
Clear Search sequence regions


  • and disease (1)
  • antibodies (1)
  • blood cells (1)
  • diagnosis (1)
  • hemostasis (1)
  • humans (1)
  • platelet (14)
  • protocol (2)
  • Sizes of these terms reflect their relevance to your search.

    Platelets are small blood cells that contribute to hemostasis, immunity, and inflammation. Characterization of platelet surface markers allows for differentiation of activated platelets from resting platelets, diagnosis of platelet disorders, and investigation of platelet biology and pathology. In this article, we describe the use of mass cytometry or "CyTOF" (mass spectroscopy detection of metal-tagged antibodies on individual cells) to measure a large number of markers on each platelet and to identify platelet subsets based on the shared expression of multiple markers. This powerful new approach provides a vastly more detailed picture of platelet immunophenotypes than conventional flow cytometry and enables investigation of the roles of platelet subsets in health and disease. © 2021 Wiley Periodicals LLC. Basic Protocol: Platelet immunophenotyping by high-dimensional mass cytometry Support Protocol: Data preprocessing. © 2021 Wiley Periodicals LLC.

    Citation

    Benjamin E J Spurgeon, Alan D Michelson, Andrew L Frelinger. Platelet Immunophenotyping by High-Dimensional Mass Cytometry. Current protocols. 2021 May;1(5):e112

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 33950581

    View Full Text