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Two new arabinofuranosidetridecanol, namely 1,2-tridecanediol-1-O-α-L-5'-acetylarabinofuranoside (1) and 1,2-tridecanediol-1-O-α-L-arabinofuranoside (2) together with known compound, 1,2-tridecanediol (3) were isolated from Commiphora merkeri exudate. Compound 1 showed larvicidal activity against Ae. aegypti (LC50 = 40.66 µg/mL), An. gambiae (LC50 = 22.86 µg/mL) and Cx. quinquefasciatus (LC50 = 15.88 µg/mL). Also, Compound 2 had larvicidal activity against Ae. aegypti (LC50 = 33.79 µg/mL), An. gambiae (LC50 = 31.99 µg/mL) and Cx. quinquefasciatus (LC50 = 17.70 µg/mL). There were no significant difference of larvae mortalities (≥ 95%) among the two compounds and among mosquito species except for compound 2 at 72 h for Cx. quinquefasciatus and An. gambiae. Compound 3 was not larvicidal active even after 72 h of exposure time. In addition, none of the compound was cytotoxic to brine shrimps. The two Arabinofuranosidetridecanol are potential against mosquito species and they could be safe in the environment.

Citation

Baraka Samwel, Ester Innocent, Francis Machumi, William N Kisinza, Matthias Heydenreich. Two mosquito larvicidal arabinofuranosidetridecanol from Commiphora merkeri exudate. Natural product research. 2022 Jun;36(11):2821-2829

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PMID: 34044677

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