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    Toll-like receptor 4 (TLR4) recognizes various protein ligands; however, the protein-TLR4 binding model is unclear. Here we demonstrate a Crenomytilus grayanus lectin (CGL)-TLR4/MD2 model to show that CGL interacts with a TLR4/myeloid differentiation factor 2 (MD2) complex independently of sugar-binding properties. CGL could suppress lipopolysaccharide-induced immune responses significantly, suggesting that TLR4 itself has potential as a therapeutic target.

    Citation

    Shin-Tai Chen, Jiahn-Haur Liao, Kai-Fa Huang, I-Ming Lee, Wei-Ting Wong, Shih-Hsiung Wu, Kuo-Feng Hua. A GalNAc/Gal-specific lectin modulates immune responses via toll-like receptor 4 independently of carbohydrate-binding ability. Chemical communications (Cambridge, England). 2021 Jun 22;57(50):6209-6212

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    PMID: 34059855

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