Correlation Engine 2.0
Clear Search sequence regions

  • behavior (1)
  • ethanol (1)
  • glycol (9)
  • Hoff (2)
  • methanol (1)
  • mono (1)
  • n butanol (1)
  • n propanol (1)
  • research (1)
  • resveratrol (2)
  • solvents (5)
  • trans- resveratrol (10)
  • Sizes of these terms reflect their relevance to your search.

    This research deals with the determination of solubility, Hansen solubility parameters, dissolution properties, enthalpy-entropy compensation, and computational modeling of a naturally-derived bioactive compound trans-resveratrol (TRV) in water, methanol, ethanol, n-propanol, n-butanol, propylene glycol (PG), and various PG + water mixtures. The solubility of TRV in six different mono-solvents and various PG + water mixtures was determined at 298.2-318.2 K and 0.1 MPa. The measured experimental solubility values of TRV were regressed using six different computational/theoretical models, including van't Hoff, Apelblat, Buchowski-Ksiazczak λh, Yalkowsly-Roseman, Jouyban-Acree, and van't Hoff-Jouyban-Acree models, with average uncertainties of less than 3.0%. The maxima of TRV solubility in mole fraction was obtained in neat PG (2.62 × 10-2) at 318.2 K. However, the minima of TRV solubility in the mole fraction was recorded in neat water (3.12 × 10-6) at 298.2 K. Thermodynamic calculation of TRV dissolution properties suggested an endothermic and entropy-driven dissolution of TRV in all studied mono-solvents and various PG + water mixtures. Solvation behavior evaluation indicated an enthalpy-driven mechanism as the main mechanism for TRV solvation. Based on these data and observations, PG has been chosen as the best mono-solvent for TRV solubilization.


    Mohammed Ghazwani, Prawez Alam, Mohammed H Alqarni, Hasan S Yusufoglu, Faiyaz Shakeel. Solubilization of Trans-Resveratrol in Some Mono-Solvents and Various Propylene Glycol + Water Mixtures. Molecules (Basel, Switzerland). 2021 May 21;26(11)

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 34064283

    View Full Text