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The nuclear pore complex (NPC) is a highly conserved channel in the nuclear envelope that mediates mRNA export to the cytosol and bidirectional protein transport. Many chromosomal loci physically interact with nuclear pore proteins (Nups), and interactions with Nups can promote transcriptional repression, transcriptional activation, and transcriptional poising. Interaction with the NPC also affects the spatial arrangement of genes, interchromosomal clustering, and folding of topologically associated domains. Thus, the NPC is a spatial organizer of the genome and regulator of genome function. Copyright © 2022 Cold Spring Harbor Laboratory Press; all rights reserved.

Citation

Michael Chas Sumner, Jason Brickner. The Nuclear Pore Complex as a Transcription Regulator. Cold Spring Harbor perspectives in biology. 2022 Jan 04;14(1)

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PMID: 34127448

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