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This review recapitulates the recent knowledge accumulation on overgrowth syndrome related to gain of function of the phosphoinositide3 kinase (PI3K)-alpha. These disorders, known as PIK3CA related overgrowth syndromes (PROS) are caused by somatic PIK3CA mutation occurring during embryogenesis. We summarize here the currently available animal models and new treatments undergoing development.

Citation

Quitterie Venot, Guillaume Canaud. PIK3CA-related overgrowth spectrum: animal model and drug discovery. Comptes rendus biologies. 2021 Jul 02;344(2):189-201

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PMID: 34213856

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