IL-1α is an upstream component of the senescence-associated secretory phenotype. In this issue, Leon et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202008101) show that DOT1L-mediated H3K79 methylation at the IL1A gene plays a key role in its induction during oncogene-induced senescence. © 2021 Olan and Narita.
Ioana Olan, Masashi Narita. Putting the DOT on IL1A. The Journal of cell biology. 2021 Aug 02;220(8)
PMID: 34254986
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