Correlation Engine 2.0
Clear Search sequence regions


  • adult (1)
  • beet (2)
  • carotenoid (2)
  • ethanol (1)
  • lutein (3)
  • mice (1)
  • neoxanthin (7)
  • solvent (1)
  • spinach (2)
  • vegetables (1)
  • Sizes of these terms reflect their relevance to your search.

    The present study aimed to investigate the effect of young leaves on fat accumulation in differentiated 3T3-L1 adipocytes. A potent preventive effect on fat accumulation was observed in fractions of young leaves of spinach, beet, and arugula extracted with a low-polarity solvent (hexane:acetone:ethanol:toluene = 10:6:7:6). This effect was seemingly associated with the leaf carotenoid content, including lutein, β-carotene, and neoxanthin. Among these, only neoxanthin, with the characteristic structure of 5,6-monoepoxide and an allenic bond, significantly prevented fat accumulation in a dose-dependent manner. The preventive effect and carotenoid content, including neoxanthin, of these young leaves did not differ from those of the corresponding adult leaves. Therefore, our study demonstrated that young vegetable leaves, such as spinach, beet, and arugula leaves, contained neoxanthin, which prevented fat accumulation in adipocytes in vitro. In the future, the effectiveness of such young leaves and neoxanthin should be investigated in vivo. © The Author(s) 2021. Published by Oxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry.

    Citation

    Mihoko Sekiya, Shigenori Suzuki, Yusuke Ushida, Hiroyuki Suganuma. Neoxanthin in young vegetable leaves prevents fat accumulation in differentiated adipocytes. Bioscience, biotechnology, and biochemistry. 2021 Sep 22;85(10):2145-2152

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 34329384

    View Full Text