Tingting Geng, Duomeng Yang, Tao Lin, Andrew G Harrison, Binsheng Wang, Blake Torrance, Kepeng Wang, Yanlin Wang, Long Yang, Laura Haynes, Gong Cheng, Anthony T Vella, Erol Fikrig, Penghua Wang
bioRxiv : the preprint server for biology 2021 Aug 24Hematopoiesis is finely regulated to enable timely production of the right numbers and types of mature immune cells to maintain tissue homeostasis. Dysregulated hematopoiesis may compromise antiviral immunity and/or exacerbate immunopathogenesis. Herein, we report an essential role of UBXN3B in maintenance of hematopoietic homeostasis and restriction of immunopathogenesis during respiratory viral infection. Ubxn3b deficient ( Ubxn3b -/- ) mice are highly vulnerable to SARS-CoV-2 and influenza A infection, characterized by more severe lung immunopathology, lower virus-specific IgG, significantly fewer B cells, but more myeloid cells than Ubxn3b +/+ littermates. This aberrant immune compartmentalization is recapitulated in uninfected Ubxn3b -/- mice. Mechanistically, UBXN3B controls precursor B-I (pre-BI) transition to pre-BII and subsequent proliferation in a cell-intrinsic manner, by maintaining BLNK protein stability and pre-BCR signaling. These results reveal an essential role of UBXN3B for the early stage of B cell development.
Tingting Geng, Duomeng Yang, Tao Lin, Andrew G Harrison, Binsheng Wang, Blake Torrance, Kepeng Wang, Yanlin Wang, Long Yang, Laura Haynes, Gong Cheng, Anthony T Vella, Erol Fikrig, Penghua Wang. An Essential Role of UBXN3B in B Lymphopoiesis. bioRxiv : the preprint server for biology. 2021 Aug 24
PMID: 34462748
View Full Text