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The aim of this study was to investigate the prognostic value of arginase-1 (Arg-1) and glypican-3 (GPC-3) in patients with intrahepatic cholangiocarcinoma (ICC). Two hundred and thirty-seven patients with ICC were included in this study. All patients had undergone radical surgery and had complete clinical information. Immunohistochemistry was used to assess the levels of Arg-1 and GPC-3 in ICC tissues. Univariate and multivariate analyses were conducted to identify independent risk factors in ICC. The relationship between Arg-1 and GPC-3 levels and patient survival was determined using the Kaplan-Meier method. High Arg-1 and GPC-3 expression levels were associated with poor prognosis in patients with ICC, and they could be as new prognostic biomarkers in ICC. Arg-1 and GPC-3 can serve as independent prognostic biomarkers in ICC. © 2021. The Author(s).

Citation

Zeyuan Qiang, Haofeng Zhang, Shuai Jin, Cao Yan, Zhen Li, Lianyuan Tao, Haibo Yu. The prognostic value of arginase-1 and glypican-3 expression levels in patients after surgical intrahepatic cholangiocarcinoma resection. World journal of surgical oncology. 2021 Oct 29;19(1):316

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PMID: 34715880

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