Zeyuan Qiang, Haofeng Zhang, Shuai Jin, Cao Yan, Zhen Li, Lianyuan Tao, Haibo Yu
World journal of surgical oncology 2021 Oct 29The aim of this study was to investigate the prognostic value of arginase-1 (Arg-1) and glypican-3 (GPC-3) in patients with intrahepatic cholangiocarcinoma (ICC). Two hundred and thirty-seven patients with ICC were included in this study. All patients had undergone radical surgery and had complete clinical information. Immunohistochemistry was used to assess the levels of Arg-1 and GPC-3 in ICC tissues. Univariate and multivariate analyses were conducted to identify independent risk factors in ICC. The relationship between Arg-1 and GPC-3 levels and patient survival was determined using the Kaplan-Meier method. High Arg-1 and GPC-3 expression levels were associated with poor prognosis in patients with ICC, and they could be as new prognostic biomarkers in ICC. Arg-1 and GPC-3 can serve as independent prognostic biomarkers in ICC. © 2021. The Author(s).
Zeyuan Qiang, Haofeng Zhang, Shuai Jin, Cao Yan, Zhen Li, Lianyuan Tao, Haibo Yu. The prognostic value of arginase-1 and glypican-3 expression levels in patients after surgical intrahepatic cholangiocarcinoma resection. World journal of surgical oncology. 2021 Oct 29;19(1):316
PMID: 34715880
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