Correlation Engine 2.0
Clear Search sequence regions


  • basophils (1)
  • blood cell (1)
  • breast cancer (3)
  • breast neoplasms (1)
  • cancer (2)
  • cellular (1)
  • concept (2)
  • cytokines (1)
  • eosinophils (1)
  • female (1)
  • flavin (11)
  • glycols (2)
  • humans (1)
  • il 10 (1)
  • IL 1β (1)
  • IL 6 (1)
  • mice (1)
  • monocytes (1)
  • neutrophils (1)
  • NP2 (1)
  • nude mice (2)
  • serum (1)
  • thymus (1)
  • TNF α (1)
  • Sizes of these terms reflect their relevance to your search.

    Flavin adenine dinucleotide (FAD) plays a key role in an extensive range of cellular oxidation-reduction reactions, which is engaged in metabolic pathways. The purpose of this study was to realize pegylated flavins formulation, named FAD and FAD-PEG diacid complex as theranostic tool in cancer therapy. For this objective, a murine breast cancer model, which was induced by mouse-derived4T1 breast cancer cells was studied to assess the therapeutic efficacy of FAD (named NP1) and FAD-PEG diacid complex (named NP2). The cytokines were monitored to evaluate the serum inflammatory factors to develop the blood cell content of different groups of nude mice. The experimental model shows that an intravenous injection of FAD (NP1) can significantly reduce tumour volume, tumour index and thymus index, and decrease neutrophils (NE), monocytes (MO), eosinophils (EO), and basophils (BA). At the same time, the content of IL-1α, IL-12P70, TNF α, IL-1β and IL-6 was significantly reduced, and the content of IL-10 was significantly increased. These results provide the proof-of-concept for FAD as a smart adjuvant for cancer therapy and encourages their further development in the field of Nanomedicine. © The author(s).

    Citation

    Celia Arib, Hui Liu, Qiqian Liu, Anne-Marie Cieutat, Didier Paleni, Xiaowu Li, Jolanda Spadavecchia. Flavin Adenine Dinucleotide (FAD) Pegylated (PEG)-Complexes: Proof of Concept (PoC) of theranostic tool on a Murine Breast Cancer Model. Nanotheranostics. 2022;6(2):175-183

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 34976592

    View Full Text