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Daratumumab is approved for newly diagnosed or relapsed/refractory multiple myeloma (MM). The use of daratumumab has improved patient outcomes but has changed the frequency and epidemiology of infections. However, the optimal approach to prophylaxis and supportive therapy for daratumumab-emergent infections is unknown and represents an unmet clinical need in MM. Consequently, an expert panel convened to compose recommendations for optimal infection control in patient candidates to or under daratumumab treatment for MM. Scientific evidence on infections secondary to daratumumab was evaluated, and a consensus was developed by group discussion for key questions selected according to the clinical relevance. The following key issues were addressed: infectious risk assessment and risk stratification, infection mitigation strategies, and management of infectious complications in patients with MM treated with daratumumab. Copyright © 2022 Elsevier B.V. All rights reserved.

Citation

Corrado Girmenia, Michele Cavo, Alessandro Corso, Francesco Di Raimondo, Pellegrino Musto, Massimo Offidani, Maria Teresa Petrucci, Antonio Rosato, Giovanni Barosi. Management of infectious risk of daratumumab therapy in multiple myeloma: A consensus-based position paper from an ad hoc Italian expert panel. Critical reviews in oncology/hematology. 2022 Apr;172:103623

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PMID: 35151867

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