Dinesh Rakheja, Jason Y Park, Neil J Fernandes, Tanya C Watt, Theodore W Laetsch, Rebecca R J Collins
International journal of surgical pathology 2022 SepWe describe two poorly differentiated, non-myofibroblastic (SMA-, S100+, CD34±), spindle cell neoplasms with immunohistochemical positivity for ALK and with ALK gene rearrangements leading to PLEKHH2::ALK and CLTC::ALK fusions, respectively. ALK protein overexpression and/or gene fusions should be evaluated in poorly differentiated spindle cell neoplasms, even when there is an absence of a myofibroblastic phenotype. A positive ALK evaluation has therapeutic implications as both tumors responded to single-agent treatment with the tyrosine kinase inhibitor crizotinib.
Dinesh Rakheja, Jason Y Park, Neil J Fernandes, Tanya C Watt, Theodore W Laetsch, Rebecca R J Collins. Pediatric Non-Myofibroblastic Primitive Spindle Cell Tumors with ALK Gene Rearrangements and Response to Crizotinib. International journal of surgical pathology. 2022 Sep;30(6):706-715
PMID: 35164578
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