Correlation Engine 2.0
Clear Search sequence regions


  • ALK (7)
  • CLTC (1)
  • crizotinib (4)
  • gene (4)
  • humans (1)
  • myofibroblasts (1)
  • PLEKHH2 (1)
  • Sizes of these terms reflect their relevance to your search.

    We describe two poorly differentiated, non-myofibroblastic (SMA-, S100+, CD34±), spindle cell neoplasms with immunohistochemical positivity for ALK and with ALK gene rearrangements leading to PLEKHH2::ALK and CLTC::ALK fusions, respectively. ALK protein overexpression and/or gene fusions should be evaluated in poorly differentiated spindle cell neoplasms, even when there is an absence of a myofibroblastic phenotype. A positive ALK evaluation has therapeutic implications as both tumors responded to single-agent treatment with the tyrosine kinase inhibitor crizotinib.

    Citation

    Dinesh Rakheja, Jason Y Park, Neil J Fernandes, Tanya C Watt, Theodore W Laetsch, Rebecca R J Collins. Pediatric Non-Myofibroblastic Primitive Spindle Cell Tumors with ALK Gene Rearrangements and Response to Crizotinib. International journal of surgical pathology. 2022 Sep;30(6):706-715

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 35164578

    View Full Text