Correlation Engine 2.0
Clear Search sequence regions


  • cancer (2)
  • gene clusters (1)
  • genes (1)
  • humans (1)
  • leukemia (6)
  • mirna (3)
  • mirnas (5)
  • t cell subsets (1)
  • t- cell (6)
  • Sizes of these terms reflect their relevance to your search.

    Deregulation of micro(mi)-RNAs is a common mechanism in tumorigenesis. We investigated the expression of 2083 miRNAs in T-cell prolymphocytic leukemia (T-PLL). Compared to physiologic CD4+ and CD8+ T-cell subsets, 111 miRNAs were differentially expressed in T-PLL. Of these, 33 belonged to miRNA gene clusters linked to cancer. Genomic variants affecting miRNAs were infrequent with the notable exception of copy number aberrations. Remarkably, we found strong upregulation of the miR-200c/-141 cluster in T-PLL to be associated with DNA hypomethylation and active promoter marks. Our findings suggest that copy number aberrations and epigenetic changes could contribute to miRNA deregulation in T-PLL. © 2022 The Authors. Genes, Chromosomes and Cancer published by Wiley Periodicals LLC.

    Citation

    Paurnima Patil, Sina Hillebrecht, Emil Chteinberg, Cristina López, Umut H Toprak, Julian Seufert, Stephan H Bernhart, Helene Kretzmer, Anke K Bergmann, Susanne Bens, Josef Högel, Annika Müller, Billy Michael Jebaraj, Alexandra Schrader, Patricia Johansson, Dolors Costa, Matthias Schlesner, Jan Dürig, Marco Herling, Elias Campo, Stephan Stilgenbauer, Laura Wiehle, Reiner Siebert. T-cell prolymphocytic leukemia is associated with deregulation of oncogenic microRNAs on transcriptional and epigenetic level. Genes, chromosomes & cancer. 2022 Jul;61(7):432-436

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 35218115

    View Full Text