Paurnima Patil, Sina Hillebrecht, Emil Chteinberg, Cristina López, Umut H Toprak, Julian Seufert, Stephan H Bernhart, Helene Kretzmer, Anke K Bergmann, Susanne Bens, Josef Högel, Annika Müller, Billy Michael Jebaraj, Alexandra Schrader, Patricia Johansson, Dolors Costa, Matthias Schlesner, Jan Dürig, Marco Herling, Elias Campo, Stephan Stilgenbauer, Laura Wiehle, Reiner Siebert
Genes, chromosomes & cancer 2022 JulDeregulation of micro(mi)-RNAs is a common mechanism in tumorigenesis. We investigated the expression of 2083 miRNAs in T-cell prolymphocytic leukemia (T-PLL). Compared to physiologic CD4+ and CD8+ T-cell subsets, 111 miRNAs were differentially expressed in T-PLL. Of these, 33 belonged to miRNA gene clusters linked to cancer. Genomic variants affecting miRNAs were infrequent with the notable exception of copy number aberrations. Remarkably, we found strong upregulation of the miR-200c/-141 cluster in T-PLL to be associated with DNA hypomethylation and active promoter marks. Our findings suggest that copy number aberrations and epigenetic changes could contribute to miRNA deregulation in T-PLL. © 2022 The Authors. Genes, Chromosomes and Cancer published by Wiley Periodicals LLC.
Paurnima Patil, Sina Hillebrecht, Emil Chteinberg, Cristina López, Umut H Toprak, Julian Seufert, Stephan H Bernhart, Helene Kretzmer, Anke K Bergmann, Susanne Bens, Josef Högel, Annika Müller, Billy Michael Jebaraj, Alexandra Schrader, Patricia Johansson, Dolors Costa, Matthias Schlesner, Jan Dürig, Marco Herling, Elias Campo, Stephan Stilgenbauer, Laura Wiehle, Reiner Siebert. T-cell prolymphocytic leukemia is associated with deregulation of oncogenic microRNAs on transcriptional and epigenetic level. Genes, chromosomes & cancer. 2022 Jul;61(7):432-436
PMID: 35218115
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