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Quercitrin is a naturally available type of flavonoid that commonly functions as the dietary ingredient and supplement. So far, a wide spectrum of bioactivities of quercitrin have been revealed, including antioxidative stress, antiinflammation, anti-microorganisms, immunomodulation, analgesia, wound healing, and vasodilation. Based on these various pharmacological activities, increasing studies have focused on the potency of quercitrin in diverse diseases in recent years, such as bone metabolic diseases, gastrointestinal diseases, cardiovascular and cerebrovascular diseases, and others. In this paper, by collecting and summarizing publications from the recent years, the natural sources, pharmacological activities and roles in various diseases, pharmacokinetics, structure-activity relationship, as well as the toxicity of quercitrin were systematically reviewed. In addition, the underlying molecular mechanisms of quercitrin in treating related diseases, the dose-effect relationships, and the novel preparations were discussed on the purpose of broadening the application prospect of quercitrin as functional food and providing reference for its clinical application. Notably, clinical studies of quercitrin are insufficient at present, further high-quality studies are needed to firmly establish the clinical efficacy of quercitrin. © 2022 John Wiley & Sons Ltd.

Citation

Junren Chen, Gangmin Li, Chen Sun, Fu Peng, Lei Yu, Yan Chen, Yuzhu Tan, Xiaoyu Cao, Yunli Tang, Xiaofang Xie, Cheng Peng. Chemistry, pharmacokinetics, pharmacological activities, and toxicity of Quercitrin. Phytotherapy research : PTR. 2022 Apr;36(4):1545-1575

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PMID: 35253930

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