PTB: Not just a polypyrimidine tract-binding protein.

Shirui Dai, Chao Wang, Cheng Zhang, Lemeng Feng, Wulong Zhang, Xuezhi Zhou, Ye He, Xiaobo Xia, Baihua Chen, Weitao Song

Journal of cellular physiology 2022 May

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Polypyrimidine tract-binding protein (PTB), as a member of the heterogeneous nuclear ribonucleoprotein family, functions by rapidly shuttling between the nucleus and the cytoplasm. PTB is involved in the alternative splicing of pre-messenger RNA (mRNA) and almost all steps of mRNA metabolism. PTB regulation is organ-specific; brain- or muscle-specific microRNAs and long noncoding RNAs partially contribute to regulating PTB, thereby modulating many physiological and pathological processes, such as embryonic development, cell development, spermatogenesis, and neuron growth and differentiation. Previous studies have shown that PTB knockout can inhibit tumorigenesis and development. The knockout of PTB in glial cells can be reprogrammed into functional neurons, which shows great promise in the field of nerve regeneration but is controversial. © 2022 Wiley Periodicals LLC.

Citation

Shirui Dai, Chao Wang, Cheng Zhang, Lemeng Feng, Wulong Zhang, Xuezhi Zhou, Ye He, Xiaobo Xia, Baihua Chen, Weitao Song. PTB: Not just a polypyrimidine tract-binding protein. Journal of cellular physiology. 2022 May;237(5):2357-2373