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    This review of aspirin-exacerbated respiratory disease (AERD) describes the clinical characteristics and pathophysiology of disease, highlighting its similarities and unique differences in comparison to classic IgE mediated hypersensitivity as well as AERD as a chronic disease. There is a specific focus on the comparison of mediator production over time and the use of desensitization in each diagnosis that serves to aid the clinician in differentiating aspirin reactions in AERD from those related to true immediate hypersensitivity. Copyright © 2021 Elsevier Inc. All rights reserved.


    Kristen B Corey, Katherine N Cahill. Aspirin-Exacerbated Respiratory Disease: A Unique Case of Drug Hypersensitivity. Immunology and allergy clinics of North America. 2022 May;42(2):421-432

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    PMID: 35469627

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