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    Elemental sulfur enables the convenient formation of C-S bonds and the direct incoporation of S-S bonds. The reactivity of easily accessible electron deficient alkenes towards sulfur, however, is barely disclosed. Herein, we investigated the reactivity of acrylamides with sulfur and eventually developed a new pseudo-multicomponent reaction for the preparation of polysulfides. Sequential one-pot reduction led to diversely substituted thiols. Additional third stage one-pot modifications provided thioethers, unsymmetric disulfide and thioester.

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    András Gy Németh, Renáta Szabó, Krisztina Németh, György M Keserű, Péter Ábrányi-Balogh. A stepwise one-pot synthesis of aliphatic thiols and their derivatives from acrylamides and sulfur. Organic & biomolecular chemistry. 2022 Jun 01;20(21):4361-4368

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    PMID: 35575267

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