Correlation Engine 2.0
Clear Search sequence regions


  • 1 protein (1)
  • antibodies (8)
  • antigens (13)
  • APC 1 (2)
  • asthma (2)
  • ATG16L1 (2)
  • ATG2a (1)
  • ATG5 (5)
  • ATG7 (87)
  • autoantibodies (15)
  • autoantigens (5)
  • b lymphocytes (35)
  • BAFF (10)
  • BECN1 (17)
  • bis tris (1)
  • blood (2)
  • blood cells (1)
  • blue (2)
  • bone marrow (6)
  • borrelia burgdorferi (2)
  • b‐ factor (3)
  • b‐ lymphocyte (1)
  • c 100 (1)
  • catalog (29)
  • CD115 (6)
  • CD11b (6)
  • CD11c (4)
  • CD45R (1)
  • cell numbers (10)
  • cenp (1)
  • chemotaxis (1)
  • chronic diseases (2)
  • colitis (1)
  • complement c1q (1)
  • cytokines (29)
  • cytosol (1)
  • dapi (1)
  • direct (5)
  • endotoxemia (7)
  • Eric (1)
  • fiji (1)
  • fip200 (1)
  • flow (4)
  • formalin (1)
  • FoxP3 (5)
  • genes proteins (2)
  • genotypes (5)
  • gtpase (2)
  • Hank (1)
  • horseradish (1)
  • human (11)
  • human cells (1)
  • ice (1)
  • IFN (3)
  • IFNα (3)
  • igg1 (1)
  • il 1 (6)
  • il 10 (54)
  • il 12 (17)
  • il 17 (4)
  • IL 17A (9)
  • il 18 (13)
  • il 22 (2)
  • IL 23 (12)
  • IL 6 (42)
  • Il10 (10)
  • immunoglobulin g (1)
  • immunoglobulin g (1)
  • interferon (2)
  • interferon‐ γ (10)
  • interleukin (169)
  • knockout mice (15)
  • kolmogorov smirnov tests (1)
  • layers (1)
  • LC3 (10)
  • lc3‐ associated phagocytosis (25)
  • ligand (4)
  • loss weight (1)
  • lupus (19)
  • Ly6C (2)
  • lyme disease (1)
  • lymphocytes (2)
  • macrophages (26)
  • Map1lc3b (1)
  • MHC I (3)
  • MHC II (4)
  • monocytes (3)
  • MyD88 (3)
  • myeloid cells (64)
  • necrosis (7)
  • neutrophils (1)
  • NLRP3 (1)
  • nonreceptor (1)
  • nuclear antigens (4)
  • organelles (1)
  • paraffin (1)
  • patients (4)
  • pcna (2)
  • pcr (5)
  • peanut agglutinin (1)
  • penicillin (1)
  • Pervin (1)
  • plasma (1)
  • plasma cells (18)
  • plex (2)
  • PmScl (2)
  • propidium (1)
  • protein knockdown (1)
  • protein levels (1)
  • proteinuria (2)
  • protocol (5)
  • pyrin (1)
  • r 848 (15)
  • rapamycin (2)
  • regulates (2)
  • renal disease (1)
  • research (1)
  • ribosomes (5)
  • rna (24)
  • RNP (3)
  • Rubcn (1)
  • r‐ 4 h (1)
  • salt (1)
  • Sarah (1)
  • sepsis (2)
  • serum (35)
  • serum albumin (3)
  • signal (2)
  • slides (1)
  • sodium (3)
  • spleen (9)
  • streptomycin (1)
  • susceptibility disease (1)
  • suspensions (1)
  • switzerland (2)
  • t cells (8)
  • TLR (5)
  • TLR4 (2)
  • TLR7 (5)
  • TRIM21 (5)
  • tris (1)
  • triton x‐ 100 (2)
  • tumor antigens (1)
  • tumor necrosis factor (2)
  • tween 20 (2)
  • unc‐ 51 like (1)
  • Uvrag (1)
  • viral antigens (1)
  • weight (10)
  • western blot (3)
  • Sizes of these terms reflect their relevance to your search.

    Studies have highlighted a critical role for autophagy in the regulation of multiple cytokines. Autophagy inhibits the release of interleukin (IL)-1 family cytokines, including IL-1α, IL-1β and IL-18, by myeloid cells. This, in turn, impacts the release of other cytokines by myeloid cells, as well as other cells of the immune system, including IL-22, IL-23, IL-17 and interferon-γ. Here, we assessed the impact of genetic depletion of the autophagy gene Atg7 in myeloid cells on acute and chronic inflammation. In a model of acute lipopolysaccharide-induced endotoxemia, loss of autophagy in myeloid cells resulted in increased release of proinflammatory cytokines, both locally and systemically. By contrast, loss of Atg7 in myeloid cells in the Lyn-/- model of lupus-like autoimmunity resulted in reduced systemic release of IL-6 and IL-10, with no effects on other cytokines observed. In addition, Lyn-/- mice with autophagy-deficient myeloid cells showed reduced expression of autoantibodies relevant to systemic lupus erythematosus, including anti-histone and anti-Smith protein. In vitro, loss of autophagy, through pharmacological inhibition or small interfering RNA against Becn1, inhibited IL-10 release by human and mouse myeloid cells. This effect was evident at the level of Il10 messenger RNA expression. Our data highlight potentially important differences in the role of myeloid cell autophagy in acute and chronic inflammation and demonstrate a direct role for autophagy in the production and release of IL-10 by macrophages. © 2022 The Authors. Immunology & Cell Biology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc.

    Citation

    Md Abul Hasnat, IanIan Cheang, Wendy Dankers, Jacinta Pw Lee, Lynda M Truong, Mehnaz Pervin, Sarah A Jones, Eric F Morand, Joshua D Ooi, James Harris. Investigating immunoregulatory effects of myeloid cell autophagy in acute and chronic inflammation. Immunology and cell biology. 2022 Jun 21;100(8):605-623

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 35652357

    View Full Text