Opioids are commonly administered to infants having surgery. Opioid induced hyperalgesia (OIH) is a known adverse effect of opioids in adults but can be difficult to identify in infants. A 3-month-old received high-dose fentanyl during anorectoplasty for imperforate anus. He had signs and symptoms of OIH immediately after surgery. His pain and agitation were difficult to manage but improved after he received ketamine. OIH should be considered in infants postoperatively when pain worsens despite administration of escalating doses of opioids. Ketamine can be an effective therapeutic for OIH. © 2022 John Wiley & Sons Ltd.
Proshad N Efune, Sarah E Rebstock. Suspected opioid-induced hyperalgesia in an infant following surgery: A case report. Journal of clinical pharmacy and therapeutics. 2022 Sep;47(9):1486-1489
PMID: 35968556
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