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Environmental toxicant exposure, according to many researchers in the field, is the leading cause of chronic disease and premature death globally. For the purposes of this review, we will use obesity and type 2 diabetes as examples of toxicant-induced chronic diseases. Endocrine Disrupting chemicals (EDCs) such as phthalates and bisphenols, per- and polyfluoroalkyl substances (PFAS), and persistent organic pollutants (POPs) have been linked to increased risk for obesity and type 2 diabetes in both animal and large epidemiologic studies. These two conditions are well-documented examples of evidence for mechanisms of both adipose metabolism disruption and pancreatic cell dysfunction. The implications for health care directives to both identify, prevent, and treat these exposures are reviewed. Copyright © 2022 Elsevier Inc. All rights reserved.

Citation

Anne Marie Fine, Lyn Patrick. Environmental Medicine: Exploring the Pollutome for Solutions to Chronic Diseases. Physical medicine and rehabilitation clinics of North America. 2022 Aug;33(3):719-732

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PMID: 35989060

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