B S Falch, G M König, A D Wright, O Sticher, C K Angerhofer, J M Pezzuto, H Bachmann
Department of Pharmacy, Swiss Federal Institute of Technology (ETH), Zurich.
Planta medica 1995 AugA total of 80 lipophilic and hydrophilic extracts obtained from 20 samples of cultured freshwater and terrestrial cyanobacteria were investigated for their biological activities. Of all the extracts, 26% exhibited a significant lethal effect against brine shrimp. Out of 54 extracts tested for antimicrobial activity, 78% showed antibacterial and 45% antifungal activities. Of 30 extracts tested for cytotoxicity against KB cells, none was found to be active. Bioassay-guided fractionation of the lipophilic extracts of Fischerella ambigua led to the isolation of three compounds; ambigols A (1) and B (2), and tjipanazole D (3). Compounds 1 and 2 exhibited antibacterial, antifungal, cytotoxic, molluscicidal, and anti-inflammatory, and antiviral activities. Tjipanazole D (3) showed moderate antibacterial properties.
B S Falch, G M König, A D Wright, O Sticher, C K Angerhofer, J M Pezzuto, H Bachmann. Biological activities of cyanobacteria: evaluation of extracts and pure compounds. Planta medica. 1995 Aug;61(4):321-8
PMID: 7480178
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