J Vion-Dury, S Confort-Gouny, F Nicoli, C Dhiver, J A Gastaut, J L Gastaut, P J Cozzone
Centre de Résonance Magnétique Biologique et Médicale (CRMBM), URA CNRS 1186, Faculté de Médecine, Marseille, France.
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 1994 SepWe have examined 9 healthy volunteers and 63 HIV-patients (16 asymptomatic patients and 47 patients with clinical AIDS-dementia complex, ADC) by magnetic resonance spectroscopy (MRS) and imaging (MRI) on a Siemens Magnetom SP63 (1.5 T). Proton MRS of the brain was performed at 63 MHz using the PRESS sequence (echo time = 135 ms, TR = 1.6 s). Four main results have been found: (1) HIV-related encephalopathy induces significant modifications of brain metabolism analyzed by MRS and the most sensitive metabolic parameter is the N-acetyl-aspartate/Choline ratio, (2) the correlation between MRS and MRI is good in 75% of patients, (3) in 4 of the 16 neuro-asymptomatic patients (i.e. 25%) a metabolic encephalopathy was found while MRI was still normal, and (4) MR spectra describe 3 different pathological metabolic patterns in the brain of HIV patients. Two patterns might correspond to the two entities of HIV-induced lesions i.e. HIV encephalitis and HIV-related progressive leukoencephalopathy.
J Vion-Dury, S Confort-Gouny, F Nicoli, C Dhiver, J A Gastaut, J L Gastaut, P J Cozzone. Localized brain proton MRS metabolic patterns in HIV-related encephalopathies. Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie. 1994 Sep;317(9):833-40
PMID: 7882165
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