T Furumai, H Yamamoto, Y Narita, T Hasegawa, S Aburaki, M Kakushima, T Oki
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
The Journal of antibiotics 1993 OctIn a screen of pradimicin-nonproducing mutants derived from Actinomadura verrucosospora subsp. neohibisca R103-3, we found a strain capable of producing 11-hydroxyl analogs of pradimicins A and FA-1, designated pradimicins H and FH, respectively. Feeding of pradimicins H and FH to growing cultures of an actinomycete strain AA3798 produced 11-O-L-xylosylpradimicins H and FH, respectively. These 11-O-L-xylosylpradimicins had a broad spectrum of antifungal activity and demonstrated in vivo efficacies against Candida albicans in mice.
T Furumai, H Yamamoto, Y Narita, T Hasegawa, S Aburaki, M Kakushima, T Oki. Microbial modification of pradimicins at C-11 leading to 11-O-demethyl- and 11-O-L-xylosylpradimicins A and FA-1. The Journal of antibiotics. 1993 Oct;46(10):1589-97
PMID: 8244888
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