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QuickView for 1-ethyl-1,4-dihydro-4-oxo-7-(4-pyridinyl)-3-quinolinecarboxylic acid (compound)


PubChem
Name: rosoxacin
PubChem Compound ID: 287180
Molecular formula: C17H14N2O3
Molecular weight: 294.305 g/mol
Synonyms:
Roxadyl; Rosoxacinum [INN-Latin]; Rosoxacin (USAN); Roxadyl (TN); Win-35123; Eracine; Rosoxacin; 1-Ethyl-1,4-dihydro-4-oxo-7-(4-pyridyl)-3-quinolinecarboxylic acid; 1-Ethyl-1,4-dihydro-4-oxo-7-(4-pyridinyl)-3-quinolinecarboxylic acid; NSC 146617.
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DrugBank
Identification
Name: rosoxacin
Name (isomeric): DB00817
Drug Type: small molecule
Synonyms:
Rosoxacino [INN-Spanish]; Acrosoxacin; ROS; Rosoxacine [INN-French]
Brand: Winuron, Eradacin, Eradacil, Roxadyl, Eracine
Category: Anti-Infective Agents
CAS number: 40034-42-2
Pharmacology
Indication: For the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients.
Pharmacology:
Rosoxacin is a nonfluorinated quinolone antibiotic. Its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Rosoxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negativ...
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Mechanism of Action: Rosoxacin binds to and inhibits the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination.
Affected organisms: Enteric bacteria and other eubacteria

Targets