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QuickView for 3-hydroxy-3-methylglutaryl CoA reductase (gene)


Gene Symbol:
HMGCR Homo sapiens Homo sapiens
Full name:
3-hydroxy-3-methylglutaryl-CoA reductase
Synonyms:
LDLCQ3, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase, 3-hydroxy-3-methylglutaryl CoA reductase (NADPH), HMG-CoA reductase, hydroxymethylglutaryl-CoA reductase
Genomic Location:
Chr 5: 74668855-74693681
Description:
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization a...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Gallus gallus Bos taurus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 5
5q13.3





GO Molecular Function

hydroxymethylglutaryl-CoA reductase (NADPH) activity | oxidoreductase activity, acting on CH-OH group of donors | NADP binding | cofactor binding | protein phosphatase 2A binding | enzyme binding | nucleotide binding | coenzyme binding | catalytic activity | anion binding | identical protein binding | ion binding | organic cyclic compound binding | hydroxymethylglutaryl-CoA reductase activity | protein binding | protein homodimerization activity | protein phosphatase binding | protein dimerization activity | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | NADPH binding | phosphatase binding | heterocyclic compound binding | oxidoreductase activity | small molecule binding

GO Biological Process

positive regulation of smooth muscle cell proliferation | response to extracellular stimulus | regulation of ERK1 and ERK2 cascade | negative regulation of phosphorylation | purine ribonucleotide metabolic process | regulation of blood vessel diameter | response to radiation | hydroxymethylglutaryl-CoA reductase (NADPH) activity | response to nutrient levels | negative regulation of MAPK cascade | oxidoreductase activity, acting on CH-OH group of donors | regulation of cellular localization | negative regulation of peptide secretion | positive regulation of skeletal muscle tissue development | positive regulation of apoptotic process | regulation of localization | positive regulation of striated muscle tissue development | isoprenoid biosynthetic process | regulation of programmed cell death | negative regulation of cellular process | negative regulation of kinase activity | positive regulation of developmental process | regulation of MAP kinase activity | regulation of cardiac muscle cell apoptotic process | cell differentiation | response to drug | negative regulation of protein phosphorylation | positive regulation of phosphate metabolic process | negative regulation of protein secretion | regulation of peptide hormone secretion | response to antibiotic | sterol metabolic process | cellular process | nucleotide metabolic process | negative regulation of signaling | visual learning | ribose phosphate metabolic process | learning | regulation of striated muscle tissue development | negative regulation of apoptotic process | negative regulation of secretion | positive regulation of nitrogen compound metabolic process | ribonucleotide metabolic process | positive regulation of muscle cell apoptotic process | negative regulation of hormone secretion | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | muscle structure development | negative regulation of wound healing | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of stress-activated MAPK cascade | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | cellular aromatic compound metabolic process | steroid biosynthetic process | cellular component organization | cellular lipid metabolic process | regulation of peptide secretion | positive regulation of stress-activated protein kinase signaling cascade | associative learning | response to stimulus | negative regulation of protein transport | purine nucleotide metabolic process | regulation of insulin secretion | positive regulation of protein metabolic process | regulation of blood vessel size | negative regulation of protein kinase activity | alcohol metabolic process | regulation of cell proliferation | response to alcohol | coenzyme A metabolic process | cellular nitrogen compound metabolic process | negative regulation of transport | regulation of protein transport | blood circulation | negative regulation of metabolic process | cofactor metabolic process | cellular component assembly | regulation of wound healing | regulation of peptide transport | regulation of steroid biosynthetic process | cellular biosynthetic process | regulation of steroid metabolic process | response to ethanol | negative regulation of blood vessel diameter | regulation of cellular response to stress | organic hydroxy compound metabolic process | response to light stimulus | regulation of skeletal muscle tissue development | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of secretion by cell | negative regulation of phosphate metabolic process | negative regulation of catalytic activity | regulation of MAPK cascade | phosphorus metabolic process | negative regulation of striated muscle cell apoptotic process | learning or memory | protein complex oligomerization | positive regulation of muscle organ development | regulation of catalytic activity | regulation of insulin secretion involved in cellular response to glucose stimulus | regulation of protein serine/threonine kinase activity | lipid metabolic process | regulation of phosphorylation | regulation of hormone levels | regulation of hormone secretion | regulation of cholesterol biosynthetic process | nervous system process | organophosphate metabolic process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | sterol biosynthetic process | regulation of nitrogen compound metabolic process | small molecule metabolic process | positive regulation of intracellular signal transduction | negative regulation of protein serine/threonine kinase activity | response to nutrient | nucleobase-containing small molecule metabolic process | cognition | regulation of cholesterol metabolic process | cellular ketone metabolic process | biosynthetic process | cholesterol biosynthetic process | regulation of cellular protein metabolic process | negative regulation of peptide hormone secretion | lipid biosynthetic process | protein tetramerization | response to toxic substance | ubiquinone metabolic process | phosphate-containing compound metabolic process | negative regulation of response to wounding | regulation of muscle cell apoptotic process | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | positive regulation of signal transduction | positive regulation of cell proliferation | regulation of protein phosphorylation | negative regulation of MAP kinase activity | regulation of tube size | hydroxymethylglutaryl-CoA reductase activity | regulation of lipid biosynthetic process | negative regulation of insulin secretion involved in cellular response to glucose stimulus | protein-containing complex assembly | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | visual behavior | regulation of kinase activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | metabolic process | cholesterol metabolic process | oxidation-reduction process | negative regulation of programmed cell death | regulation of tube diameter | negative regulation of muscle cell apoptotic process | regulation of secretion | behavior | positive regulation of cell death | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of cellular protein metabolic process | regulation of protein secretion | positive regulation of ERK1 and ERK2 cascade | positive regulation of programmed cell death | regulation of phosphate metabolic process | positive regulation of muscle tissue development | positive regulation of MAPK cascade | positive regulation of cardiac muscle cell apoptotic process | negative regulation of protein metabolic process | steroid metabolic process | regulation of response to wounding | regulation of stress-activated MAPK cascade | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | negative regulation of insulin secretion | myoblast differentiation | positive regulation of phosphorylation | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | isoprenoid metabolic process | regulation of developmental process | developmental process | carbohydrate derivative metabolic process | regulation of transport | quinone metabolic process | heterocycle metabolic process | regulation of lipid metabolic process | positive regulation of metabolic process | cellular metabolic process | regulation of protein localization | regulation of cell death | regulation of smooth muscle cell proliferation | oxidoreductase activity | negative regulation of cell death | aging | positive regulation of signaling | regulation of signaling | regulation of muscle organ development | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

peroxisomal membrane | integral component of membrane | intracellular membrane-bounded organelle | organelle membrane | peroxisome | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | membrane-bounded organelle | organelle | intracellular | membrane