Correlation Engine 2.0
Clear Search sequence regions
Bookmark Forward Export SNPs

QuickView for 4E-BP1 (gene)


Gene Symbol:
EIF4EBP1 Homo sapiens Homo sapiens
Full name:
eukaryotic translation initiation factor 4E binding protein 1
Synonyms:
4E-BP1, 4EBP1, BP-1, PHAS-I, eukaryotic translation initiation factor 4E-binding protein 1, eIF4E-binding protein 1, phosphorylated heat- and acid-stable protein regulated by insulin 1
Genomic Location:
Chr 8: 38007177-38037040
Description:
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly a...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 8
8p11.23


Transcripts Names
NM_004095
Protein Names
Q6IBN3
B2R502
D3DSW8
Q13541



GO Molecular Function

translation initiation factor binding | eukaryotic initiation factor 4E binding | translation repressor activity | protein binding | translation regulator activity

GO Biological Process

intracellular signal transduction | response to hormone | negative regulation of cellular process | response to dexamethasone | response to drug | cellular process | TOR signaling | regulation of cell cycle | negative regulation of cellular metabolic process | response to peptide hormone | regulation of cellular process | cellular response to lipid | regulation of metabolic process | cellular response to organonitrogen compound | IRES-dependent translational initiation of linear mRNA | regulation of translational initiation | response to stimulus | peptide biosynthetic process | cellular response to xenobiotic stimulus | cellular nitrogen compound biosynthetic process | posttranscriptional regulation of gene expression | response to peptide | cellular nitrogen compound metabolic process | cell cycle G1/S phase transition | cellular response to organic cyclic compound | negative regulation of metabolic process | cellular biosynthetic process | translational initiation | response to nitrogen compound | cellular response to hormone stimulus | nitrogen compound metabolic process | cellular response to peptide hormone stimulus | cap-independent translational initiation | cellular response to insulin stimulus | positive regulation of cell cycle | positive regulation of mitotic cell cycle | regulation of gene expression | response to ketone | response to lipid | cellular response to peptide | cell cycle | insulin receptor signaling pathway | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | response to corticosteroid | cellular amide metabolic process | translation | biosynthetic process | regulation of cellular protein metabolic process | cellular response to glucocorticoid stimulus | translation repressor activity | response to xenobiotic stimulus | mitotic cell cycle phase transition | cellular response to corticosteroid stimulus | cellular response to drug | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | G1/S transition of mitotic cell cycle | peptide metabolic process | regulation of mitotic cell cycle | protein metabolic process | response to organic substance | translation regulator activity | response to antineoplastic agent | response to insulin | mitotic cell cycle | cell surface receptor signaling pathway | metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | negative regulation of cellular protein metabolic process | gene expression | amide biosynthetic process | cellular response to steroid hormone stimulus | negative regulation of translation | cellular response to dexamethasone stimulus | negative regulation of protein metabolic process | signaling | response to organic cyclic compound | cellular protein metabolic process | cellular macromolecule biosynthetic process | negative regulation of translational initiation | cytoplasmic translational initiation | response to organonitrogen compound | cell cycle phase transition | transmembrane receptor protein tyrosine kinase signaling pathway | cytoplasmic translation | cellular metabolic process | cellular response to organic substance | response to steroid hormone | regulation of translation | signal transduction | response to glucocorticoid | macromolecule metabolic process

GO Cellular Component

cell | cytoplasm | cytosol | intracellular