QuickView for 53BP1 (gene)

Gene Symbol:

TP53BP1 Homo sapiens

Full name:

tumor protein p53 binding protein 1

Synonyms:

53BP1, TDRD30, TP53, p202, p53BP1, TP53-binding protein 1, tumor suppressor p53-binding protein 1, p53-binding protein 1, tumor protein 53-binding protein, 1

Genomic Location:

Chr 15: 41486699-41590028

Description:

This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitmen...

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This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  HNF4ALPHA_Q6 ,  PPARG_01 ,  TCANNTGAY_SREBP1_01 ,  EFC_Q6 ,  MIF1_01 ,  CTTTGA_LEF1_Q2 ,  COUP_01 ,  GCCATNTTG_YY1_Q6 ,  TGACCTY_ERR1_Q2 ,  RYTGCNWTGGNR_UNKNOWN ,  NFY_Q6_01 ,  RFX1_02 ,  CAGGTG_E12_Q6 ,  AP4_01 ,  AR_01 ,  ZID_01 ,  GGGCGGR_SP1_Q6 ,  OCT1_03 ,  GTTGNYNNRGNAAC_UNKNOWN ,  CTTTAAR_UNKNOWN ,  TGTYNNNNNRGCARM_UNKNOWN ,  WCTCNATGGY_UNKNOWN ,  RNGTGGGC_UNKNOWN ,  TAATTA_CHX10_01 ,  GTCNYYATGR_UNKNOWN ,  COUP_DR1_Q6 ,  ZIC2_01 ,  CAGCTG_AP4_Q5 ,  GTTRYCATRR_UNKNOWN ,  HNF4_01_B ,  GGGTGGRR_PAX4_03 ,  CCTNTMAGA_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-329 ,  Predicted Gene Targets for miR-505

Cytogenetic Map:

15q15.3

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