QuickView for ABCB11 (gene)

Gene Symbol:

ABCB11 Homo sapiens

Full name:

ATP binding cassette subfamily B member 11

Synonyms:

ABC16, BRIC2, BSEP, PFIC-2, PFIC2, PGY4, SPGP, bile salt export pump, ABC member 16, MDR/TAP subfamily, ATP-binding cassette sub-family B member 11, ATP-binding cassette, sub-family B (MDR/TAP), member 11, progressive familial intrahepatic cholestasis 2, sister p-glycoprotein

Genomic Location:

Chr 2: 169487695-169596079

Description:

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/...

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The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

WGTTNNNNNAAA_UNKNOWN ,  FXR_IR1_Q6

Cytogenetic Map:

2q31.1

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