QuickView for ABCB1 (gene)

Gene Symbol:

Abcb1a Mus musculus

Full name:

ATP-binding cassette, sub-family B (MDR/TAP), member 1A

Synonyms:

Abcb4, Evi32, Mdr1a, Mdr3, P-gp, Pgp, Pgy-3, Pgy3, mdr-3, multidrug resistance protein 1A, ATP-binding cassette sub-family B member 1A, ATP-binding cassette, sub-family B (MDR/TAP), member 4, ATP-binding cassette, subfamily B, member 1A, P-glycoprotein 3, ecotropic viral integration site 32, multi-drug resistance 3, multidrug resistance protein 3, multiple drug resistant 1a

Genomic Location:

Chr 5: 8660092-8748519

Description:

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/...

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The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a p-glycoprotein which actively transports a variety of hydrophobic amphipathic drugs and plays a major role in the blood-brain barrier permeability of certain drugs.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NKX62_Q2 ,  STAT4_01 ,  STAT5A_04 ,  CTTTAAR_UNKNOWN ,  TNCATNTCCYR_UNKNOWN ,  TTGTTT_FOXO4_01 ,  RTAAACA_FREAC2_01 ,  TATAAA_TATA_01

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