QuickView for ABCB8 (gene)
- Gene Symbol:
- ABCB8
Homo sapiens - Full name:
- ATP binding cassette subfamily B member 8
- Synonyms:
- EST328128, M-ABC1, MABC1, ATP-binding cassette sub-family B member 8, mitochondrial, ATP-binding cassette, sub-family B (MDR/TAP), member 8, mitochondrial ABC protein, mitochondrial ATP-binding cassette 1
- Genomic Location:
- Chr 7: 150356443-150375802
- Description:
-
This nuclear gene encodes a multi-pass membrane protein that is targeted to the mitochondrial inner membrane. The encoded protein is an ATP-dependent transporter that may mediate the passage of organic and inorganic molecules out of the mitochondria. Loss of function of the related gene in mouse results in a disruption of iron homeostasis between t...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
7q36.1
GO Molecular Function
ATPase activity, coupled to transmembrane movement of substances | ribonucleotide binding | transmembrane transporter activity | nucleotide binding | hydrolase activity | carbohydrate derivative binding | ATPase activity | pyrophosphatase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | nucleoside-triphosphatase activity | ATPase activity, coupled | active transmembrane transporter activity | purine nucleotide binding | transporter activity | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | hydrolase activity, acting on acid anhydrides | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | small molecule binding
GO Biological Process
ATPase activity, coupled to transmembrane movement of substances | establishment of localization | localization | transmembrane transporter activity | active transmembrane transporter activity | transmembrane transport
GO Cellular Component
integral component of membrane | organelle inner membrane | intracellular membrane-bounded organelle | catalytic complex | mitochondrial inner membrane | organelle membrane | cell | ATP-binding cassette (ABC) transporter complex | nuclear lumen | plasma membrane protein complex | intrinsic component of membrane | nucleolus | cytoplasm | intracellular organelle | protein-containing complex | plasma membrane | mitochondrion | membrane-bounded organelle | nucleus | organelle | mitochondrial envelope | cell periphery | membrane-enclosed lumen | transmembrane transporter complex | ATPase complex | mitochondrial membrane | intracellular | membrane
