QuickView for ABCC1 (gene)

Gene Symbol:

ABCC1 Homo sapiens

Full name:

ATP binding cassette subfamily C member 1

Synonyms:

ABC29, ABCC, GS-X, MRP, MRP1, multidrug resistance-associated protein 1, ATP-binding cassette transporter variant ABCC1delta-ex13, ATP-binding cassette transporter variant ABCC1delta-ex13&14, ATP-binding cassette transporter variant ABCC1delta-ex25, ATP-binding cassette transporter variant ABCC1delta-ex25&26, ATP-binding cassette, sub-family C (CFTR/MRP), member 1, LTC4 transporter, leukotriene C(4) transporter

Genomic Location:

Chr 16: 15950935-16144432

Description:

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily wh...

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The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Danio rerio ,  Schizosaccharomyces pombe ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GTGACGY_E4F1_Q6 ,  ACTGCCT_MIR34B ,  TTGTTT_FOXO4_01 ,  SP1_Q6_01

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-34b

Cytogenetic Map:

16p13.11

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