QuickView for ACE2 (gene)

Gene Symbol:

ACE2 Homo sapiens

Full name:

angiotensin I converting enzyme 2

Synonyms:

ACEH, angiotensin-converting enzyme 2, ACE-related carboxypeptidase, angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, angiotensin-converting enzyme homolog, metalloprotease MPROT15, peptidyl-dipeptidase A

Genomic Location:

Chr X: 15489077-15529058

Description:

The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cel...

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The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  TGACCTY_ERR1_Q2 ,  WTGAAAT_UNKNOWN ,  CEBPB_01 ,  CTTTAAR_UNKNOWN ,  TAATTA_CHX10_01 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  IK2_01 ,  IK3_01

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-200b

Cytogenetic Map:

Xp22.2

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