QuickView for ACSL1 (gene)

Gene Symbol:

ACSL1 Homo sapiens

Full name:

acyl-CoA synthetase long chain family member 1

Synonyms:

ACS1, FACL1, FACL2, LACS, LACS1, LACS2, long-chain-fatty-acid--CoA ligase 1, LACS 1, LACS 2, acyl-CoA synthetase 1, fatty-acid-Coenzyme A ligase, long-chain 1, fatty-acid-Coenzyme A ligase, long-chain 2, lignoceroyl-CoA synthase, long-chain acyl-CoA synthetase 1, long-chain acyl-CoA synthetase 2, long-chain fatty acid-CoA ligase 2, long-chain fatty-acid-coenzyme A ligase 1, palmitoyl-CoA ligase 1, palmitoyl-CoA ligase 2, paltimoyl-CoA ligase 1

Genomic Location:

Chr 4: 185913743-185984209

Description:

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty ...

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The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RTAAACA_FREAC2_01 ,  CACTGCC_MIR34A_MIR34C_MIR449 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  TTGCACT_MIR130A_MIR301_MIR130B ,  TGCCTTA_MIR124A ,  ACTGCCT_MIR34B ,  CAGTCAC_MIR134 ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  ATGAAGG_MIR205 ,  AAGCACA_MIR218

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-134 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-205 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-34b ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-376c ,  Predicted Gene Targets for miR-543

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Cytogenetic Map:

4q35.1

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