QuickView for ACSL4 (gene)

Gene Symbol:

ACSL4 Homo sapiens

Full name:

acyl-CoA synthetase long chain family member 4

Synonyms:

ACS4, FACL4, LACS4, MRX63, MRX68, long-chain-fatty-acid--CoA ligase 4, LACS 4, acyl-CoA synthetase 4, fatty-acid-Coenzyme A ligase, long-chain 4, lignoceroyl-CoA synthase, long-chain acyl-CoA synthetase 4, long-chain fatty-acid-Coenzyme A ligase 4

Genomic Location:

Chr X: 108771220-108863277

Description:

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty ...

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The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the cognitive disability or Alport syndrome. Alternative splicing of this gene generates multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGCC_MIR34A_MIR34C_MIR449 ,  TTTGCAC_MIR19A_MIR19B ,  TGANTCA_AP1_C ,  ETS_Q4 ,  TTANTCA_UNKNOWN ,  ZIC1_01 ,  E4BP4_01 ,  CTTTGCA_MIR527 ,  GGGACCA_MIR133A_MIR133B ,  GTGACTT_MIR224 ,  AACTGGA_MIR145 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  CAGGTG_E12_Q6 ,  GTCTTCC_MIR7 ,  ATTCTTT_MIR186 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  GCAAAAA_MIR129 ,  AREB6_01 ,  MGGAAGTG_GABP_B ,  ATACTGT_MIR144 ,  AHRARNT_01 ,  RORA1_01 ,  RNGTGGGC_UNKNOWN ,  HLF_01 ,  YGCGYRCGC_UNKNOWN ,  TTGTTT_FOXO4_01 ,  RGAGGAARY_PU1_Q6 ,  RGTTAMWNATT_HNF1_01 ,  GTGGGTGK_UNKNOWN ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  CAGCTG_AP4_Q5 ,  CDC5_01 ,  AACTTT_UNKNOWN ,  YNGTTNNNATT_UNKNOWN ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  ELF1_Q6 ,  CEBPGAMMA_Q6 ,  ACACTAC_MIR1423P

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-132 ,  Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-142-3p ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-450 ,  Predicted Gene Targets for miR-503 ,  Predicted Gene Targets for miR-7 ,  Predicted Gene Targets for miR-496 ,  Predicted Gene Targets for miR-543

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Cytogenetic Map:

Xq23

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