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QuickView for ACVR1 (gene)


Gene Symbol:
ACVR1 Homo sapiens Homo sapiens
Full name:
activin A receptor type 1
Synonyms:
ACTRI, ACVR1A, ACVRLK2, ALK2, FOP, SKR1, TSRI, activin receptor type-1, TGF-B superfamily receptor type I, activin A receptor, type I, activin A receptor, type II-like kinase 2, activin receptor type I, activin receptor-like kinase 2, hydroxyalkyl-protein kinase, serine/threonine-protein kinase receptor R1
Genomic Location:
Chr 2: 158301207-158403036
Description:
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors ...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Danio rerio Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
ACAACTT_MIR382 TGIF_01 AGCYRWTTC_UNKNOWN TAL1ALPHAE47_01 TTANTCA_UNKNOWN NFAT_Q6 GATA_C SMAD3_Q6 GCANCTGNY_MYOD_Q6 NFY_C
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 2
2q24.1





GO Molecular Function

transforming growth factor beta binding | cytokine binding | peptide binding | transforming growth factor beta-activated receptor activity | peptide hormone binding | cation binding | transmembrane signaling receptor activity | protein-containing complex binding | ribonucleotide binding | nucleotide binding | activin-activated receptor activity | carbohydrate derivative binding | protein serine/threonine kinase activity | transforming growth factor beta receptor activity, type I | growth factor binding | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | activin binding | amide binding | signaling receptor activity | purine nucleotide binding | identical protein binding | ion binding | organic cyclic compound binding | hormone binding | purine ribonucleoside triphosphate binding | activin receptor activity, type I | protein binding | protein homodimerization activity | transmembrane receptor protein serine/threonine kinase activity | protein dimerization activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | BMP receptor activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | SMAD binding | metal ion binding | heterocyclic compound binding | small molecule binding

GO Biological Process

regulation of activin receptor signaling pathway | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | cell motility | pharyngeal system development | developmental process involved in reproduction | muscle tissue development | regulation of localization | morphogenesis of an epithelium | regulation of programmed cell death | peptidyl-amino acid modification | smooth muscle cell differentiation | negative regulation of cellular process | positive regulation of developmental process | cell differentiation | endothelial cell differentiation | defense response | transforming growth factor beta-activated receptor activity | positive regulation of biomineral tissue development | positive regulation of phosphate metabolic process | positive regulation of cellular component movement | mesenchyme development | cardiac atrium morphogenesis | blood vessel morphogenesis | pattern specification process | positive regulation of cellular biosynthetic process | cellular process | regulation of cell motility | localization | epithelial tube morphogenesis | mesoderm morphogenesis | heart morphogenesis | negative regulation of signaling | determination of left/right symmetry | positive regulation of epithelial to mesenchymal transition | mesoderm development | positive regulation of pathway-restricted SMAD protein phosphorylation | multicellular organismal reproductive process | negative regulation of apoptotic process | response to growth factor | positive regulation of nitrogen compound metabolic process | pathway-restricted SMAD protein phosphorylation | regulation of bone mineralization | tissue development | regulation of cell differentiation | gamete generation | muscle structure development | muscle cell differentiation | ventricular septum morphogenesis | negative regulation of apoptotic signaling pathway | regulation of cellular process | regulation of osteoblast differentiation | regulation of apoptotic process | regulation of metabolic process | positive regulation of cellular protein metabolic process | epithelium development | response to transforming growth factor beta | branching involved in blood vessel morphogenesis | response to stimulus | peptidyl-threonine phosphorylation | vasculature development | negative regulation of activin receptor signaling pathway | mesenchymal cell development | endocardial cushion cell fate commitment | positive regulation of protein metabolic process | endocardial cushion fusion | mesoderm formation | response to stress | activin-activated receptor activity | germ cell development | activin receptor signaling pathway | tube morphogenesis | cardiac muscle tissue development | protein serine/threonine kinase activity | transforming growth factor beta receptor activity, type I | reproduction | atrioventricular valve morphogenesis | cardiovascular system development | cell cycle G1/S phase transition | positive regulation of RNA biosynthetic process | endocardial cell differentiation | protein modification process | embryo development | macromolecule modification | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | blood vessel development | regulation of nucleic acid-templated transcription | locomotion | response to BMP | endocardial cushion development | epithelial cell fate commitment | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | endothelium development | multicellular organism development | cell migration | phosphorus metabolic process | regulation of phosphorylation | regulation of ossification | determination of bilateral symmetry | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | outflow tract morphogenesis | cell cycle | endocardial cushion morphogenesis | embryonic heart tube morphogenesis | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation | animal organ morphogenesis | regulation of nitrogen compound metabolic process | regulation of cell migration | enzyme linked receptor protein signaling pathway | cardiac atrium development | cardiocyte differentiation | regulation of cellular component movement | regulation of transcription by RNA polymerase II | positive regulation of cell differentiation | negative regulation of extrinsic apoptotic signaling pathway | stem cell differentiation | positive regulation of cell migration | mitral valve development | regulation of cellular protein metabolic process | positive regulation of ossification | angiogenesis | mesenchyme morphogenesis | phosphorylation | cardiac septum morphogenesis | septum primum development | regulation of apoptotic signaling pathway | mitotic cell cycle phase transition | protein phosphorylation | phosphate-containing compound metabolic process | gastrulation with mouth forming second | neural crest cell migration | chordate embryonic development | striated muscle tissue development | cell communication | regulation of cellular metabolic process | transmembrane receptor protein serine/threonine kinase signaling pathway | inflammatory response | regulation of protein metabolic process | positive regulation of signal transduction | heart development | G1/S transition of mitotic cell cycle | regulation of protein phosphorylation | regulation of locomotion | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | striated muscle cell differentiation | embryonic morphogenesis | mitral valve morphogenesis | activin receptor activity, type I | positive regulation of osteoblast differentiation | cellular response to transforming growth factor beta stimulus | multicellular organism reproduction | embryonic organ morphogenesis | heart valve development | ventricular septum development | protein metabolic process | transmembrane receptor protein serine/threonine kinase activity | cardiac ventricle development | positive regulation of protein modification process | response to organic substance | tissue morphogenesis | branching morphogenesis of an epithelial tube | endocardium development | regulation of animal organ morphogenesis | embryonic heart tube development | anatomical structure development | mitotic cell cycle | cell surface receptor signaling pathway | metabolic process | cell fate commitment | mesenchymal cell differentiation | regulation of RNA biosynthetic process | negative regulation of programmed cell death | embryonic organ development | atrial septum primum morphogenesis | cell adhesion | positive regulation of determination of dorsal identity | protein kinase activity | heart valve morphogenesis | organic substance metabolic process | animal organ development | regulation of epithelial to mesenchymal transition involved in endocardial cushion formation | regulation of heart morphogenesis | regulation of phosphate metabolic process | muscle cell fate commitment | BMP signaling pathway involved in heart development | cell-cell adhesion | atrioventricular valve development | atrial septum development | stem cell development | morphogenesis of a branching epithelium | transforming growth factor beta receptor signaling pathway | anatomical structure formation involved in morphogenesis | cardiac muscle cell differentiation | BMP signaling pathway | BMP receptor activity | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | cell development | positive regulation of phosphorylation | cellular protein metabolic process | morphogenesis of a branching structure | anatomical structure morphogenesis | regulation of developmental process | kinase activity | developmental process | cardiac septum development | cellular protein modification process | tube development | positive regulation of transcription, DNA-templated | atrial septum morphogenesis | positive regulation of nucleic acid-templated transcription | cell cycle phase transition | neural crest cell differentiation | epithelial cell differentiation | formation of primary germ layer | positive regulation of transcription by RNA polymerase II | regulation of epithelial to mesenchymal transition | cardiac chamber development | cell adhesion involved in heart morphogenesis | cell-cell adhesion via plasma-membrane adhesion molecules | in utero embryonic development | positive regulation of metabolic process | cellular response to BMP stimulus | acute inflammatory response | gastrulation | cellular metabolic process | ameboidal-type cell migration | cellular response to organic substance | regulation of cell death | positive regulation of cell motility | negative regulation of cell death | circulatory system development | neural crest cell development | sexual reproduction | positive regulation of bone mineralization | positive regulation of cardiac epithelial to mesenchymal transition | positive regulation of signaling | signal transduction | regulation of signaling | regulation of pathway-restricted SMAD protein phosphorylation | positive regulation of gene expression | outflow tract septum morphogenesis | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | cardiac muscle cell fate commitment | regulation of phosphorus metabolic process

GO Cellular Component

integral component of membrane | catalytic complex | protein kinase complex | cell | plasma membrane protein complex | intrinsic component of membrane | receptor complex | apical part of cell | protein-containing complex | plasma membrane | transferase complex | integral component of plasma membrane | serine/threonine protein kinase complex | activin receptor complex | cell periphery | membrane | intrinsic component of plasma membrane