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QuickView for ACVR2A (gene)


Gene Symbol:
ACVR2A Homo sapiens Homo sapiens
Full name:
activin A receptor type 2A
Synonyms:
ACTRII, ACVR2, activin receptor type-2A, activin A receptor, type IIA
Genomic Location:
Chr 2: 148319040-148404863
Description:
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations ...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
PR_Q2 CTTGTAT_MIR381 CACTGTG_MIR128A_MIR128B ATGCAGT_MIR217 GTATTAT_MIR3693P GTGCCAT_MIR183 SMTTTTGT_UNKNOWN TGIF_01 TTTGCAG_MIR518A2 GATA1_03
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 2
2q22.3-q23.1





GO Molecular Function

protein self-association | transforming growth factor beta-activated receptor activity | cation binding | coreceptor activity | transmembrane signaling receptor activity | protein-containing complex binding | ribonucleotide binding | transforming growth factor beta receptor binding | nucleotide binding | signaling receptor binding | activin-activated receptor activity | carbohydrate derivative binding | cytokine receptor binding | protein serine/threonine kinase activity | inhibin binding | growth factor binding | catalytic activity | protein domain specific binding | ATP binding | anion binding | adenyl nucleotide binding | activin binding | signaling receptor activity | purine nucleotide binding | transforming growth factor beta receptor activity, type II | ion binding | organic cyclic compound binding | type I transforming growth factor beta receptor binding | purine ribonucleoside triphosphate binding | protein binding | transmembrane receptor protein serine/threonine kinase activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | BMP receptor activity | purine ribonucleotide binding | PDZ domain binding | adenyl ribonucleotide binding | drug binding | kinase activity | SMAD binding | metal ion binding | heterocyclic compound binding | small molecule binding

GO Biological Process

regulation of activin receptor signaling pathway | positive regulation of erythrocyte differentiation | positive regulation of macromolecule biosynthetic process | developmental process involved in reproduction | gonad development | insemination | regulation of immune system process | positive regulation of developmental process | male gamete generation | transforming growth factor beta-activated receptor activity | positive regulation of biomineral tissue development | positive regulation of phosphate metabolic process | pattern specification process | positive regulation of cellular biosynthetic process | cellular process | determination of left/right symmetry | reproductive system development | mesoderm development | positive regulation of pathway-restricted SMAD protein phosphorylation | multicellular organismal reproductive process | response to growth factor | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | positive regulation of activin receptor signaling pathway | regulation of bone mineralization | tissue development | regulation of cell differentiation | gamete generation | regulation of cellular process | regulation of osteoblast differentiation | regulation of metabolic process | positive regulation of cellular protein metabolic process | response to transforming growth factor beta | development of primary sexual characteristics | response to stimulus | positive regulation of immune system process | positive regulation of protein metabolic process | activin-activated receptor activity | activin receptor signaling pathway | Sertoli cell proliferation | protein serine/threonine kinase activity | reproduction | embryonic skeletal system development | positive regulation of RNA biosynthetic process | protein modification process | embryo development | macromolecule modification | anterior/posterior pattern specification | regulation of nucleic acid-templated transcription | response to BMP | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | multicellular organism development | regulation of BMP signaling pathway | phosphorus metabolic process | regulation of catalytic activity | regulation of phosphorylation | regulation of ossification | regulation of nitric-oxide synthase activity | determination of bilateral symmetry | regulation of gene expression | copulation | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | regulation of transcription by RNA polymerase II | positive regulation of cell differentiation | positive regulation of myeloid cell differentiation | cell proliferation | transforming growth factor beta receptor activity, type II | regulation of cellular protein metabolic process | positive regulation of ossification | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | gastrulation with mouth forming second | chordate embryonic development | cell communication | regulation of cellular metabolic process | transmembrane receptor protein serine/threonine kinase signaling pathway | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | regulation of cellular response to growth factor stimulus | embryonic morphogenesis | sperm ejaculation | positive regulation of osteoblast differentiation | cellular response to transforming growth factor beta stimulus | multicellular organism reproduction | development of primary male sexual characteristics | protein metabolic process | transmembrane receptor protein serine/threonine kinase activity | regionalization | positive regulation of protein modification process | response to organic substance | regulation of hemopoiesis | epithelial cell proliferation | male sex differentiation | anatomical structure development | cell surface receptor signaling pathway | metabolic process | regulation of RNA biosynthetic process | male gonad development | regulation of erythrocyte differentiation | protein kinase activity | organic substance metabolic process | mating | animal organ development | regulation of phosphate metabolic process | transforming growth factor beta receptor signaling pathway | BMP signaling pathway | BMP receptor activity | regulation of cell communication | signaling | regulation of transcription, DNA-templated | regulation of oxidoreductase activity | positive regulation of phosphorylation | cellular protein metabolic process | anatomical structure morphogenesis | reproductive structure development | regulation of developmental process | kinase activity | developmental process | spermatogenesis | cellular protein modification process | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | positive regulation of metabolic process | cellular response to BMP stimulus | skeletal system development | gastrulation | cellular metabolic process | cellular response to organic substance | sex differentiation | penile erection | sexual reproduction | positive regulation of bone mineralization | positive regulation of signaling | signal transduction | regulation of signaling | regulation of pathway-restricted SMAD protein phosphorylation | positive regulation of gene expression | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

integral component of membrane | inhibin-betaglycan-ActRII complex | catalytic complex | protein kinase complex | cell | plasma membrane protein complex | intrinsic component of membrane | cytoplasm | receptor complex | protein-containing complex | plasma membrane | transferase complex | integral component of plasma membrane | serine/threonine protein kinase complex | activin receptor complex | cell periphery | cell surface | intracellular | membrane | intrinsic component of plasma membrane