QuickView for ADORA2A (gene)
- Gene Symbol:
- ADORA2A
Homo sapiens - Full name:
- adenosine A2a receptor
- Synonyms:
- A2aR, ADORA2, RDC8, adenosine receptor A2a, adenosine receptor subtype A2a
- Genomic Location:
- Chr 22: 23153530-23168325
- Description:
-
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Canis lupus familiaris , Gallus gallus , Pan troglodytes , Danio rerio , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
OCT1_07 , OCT1_B , OCT1_01 , YATGNWAAT_OCT_C , OCT_Q6 , AP1_Q6 , OCT1_Q5_01 , OCT_C , GGGAGGRR_MAZ_Q6 , OCT1_Q6
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
22q11.23
GO Molecular Function
transmembrane signaling receptor activity | G-protein coupled glutamate receptor binding | enzyme binding | G-protein coupled receptor activity | signaling receptor binding | alpha-actinin binding | type 5 metabotropic glutamate receptor binding | cytoskeletal protein binding | signaling receptor activity | identical protein binding | protein heterodimerization activity | protein binding | protein dimerization activity | G-protein coupled receptor binding | actinin binding | G-protein coupled adenosine receptor activity | glutamate receptor binding
GO Biological Process
negative regulation of leukocyte activation | negative regulation of phosphorylation | purine ribonucleotide metabolic process | regulation of blood vessel diameter | cell morphogenesis | positive regulation of circadian rhythm | regulation of cysteine-type endopeptidase activity | negative regulation of immune system process | positive regulation of behavior | cyclic nucleotide biosynthetic process | neuron projection morphogenesis | regulation of cellular localization | intracellular signal transduction | positive regulation of apoptotic process | regulation of localization | regulation of programmed cell death | negative regulation of cysteine-type endopeptidase activity | establishment of localization | regulation of immune system process | astrocyte development | negative regulation of neuron death | negative regulation of cellular process | negative regulation of kinase activity | positive regulation of neurotransmitter secretion | negative regulation of leukocyte cell-cell adhesion | cell differentiation | excitatory postsynaptic potential | defense response | nervous system development | response to drug | negative regulation of protein phosphorylation | cell part morphogenesis | neurogenesis | prepulse inhibition | regulation of renal sodium excretion | generation of neurons | positive regulation of protein secretion | negative regulation of proteolysis | regulation of circadian sleep/wake cycle | regulation of neuron death | cellular process | regulation of catecholamine secretion | negative regulation of inflammatory response | localization | cell projection morphogenesis | positive regulation of synaptic transmission | regulation of mitochondrial membrane potential | nucleotide metabolic process | cAMP biosynthetic process | chemical synaptic transmission | neuron development | ribose phosphate metabolic process | purine nucleotide biosynthetic process | hemostasis | negative regulation of apoptotic process | regulation of proteolysis | ribonucleotide metabolic process | negative regulation of cellular metabolic process | regulation of behavior | positive regulation of acetylcholine secretion, neurotransmission | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | gliogenesis | regulation of acetylcholine secretion, neurotransmission | organic cyclic compound metabolic process | positive regulation of renal sodium excretion | cellular aromatic compound metabolic process | regulation of urine volume | cellular component organization | G-protein coupled receptor activity | regulation of peptide secretion | response to stimulus | purine nucleotide metabolic process | regulation of long-term synaptic potentiation | regulation of excretion | negative regulation of cell adhesion | regulation of blood vessel size | regulation of norepinephrine secretion | response to stress | negative regulation of lymphocyte activation | negative regulation of protein kinase activity | cellular nitrogen compound biosynthetic process | regulation of response to drug | cyclic purine nucleotide metabolic process | regulation of cell proliferation | positive regulation of long-term synaptic potentiation | programmed cell death | cellular nitrogen compound metabolic process | positive regulation of hormone secretion | carbohydrate derivative biosynthetic process | regulation of protein transport | blood circulation | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | regulation of peptide transport | modulation of chemical synaptic transmission | regulation of cell adhesion | cellular biosynthetic process | positive regulation of synaptic transmission, glutamatergic | cell-cell signaling | synaptic transmission, dopaminergic | cell surface receptor signaling pathway involved in cell-cell signaling | nucleotide biosynthetic process | blood coagulation | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | regulation of membrane potential | regulation of neurotransmitter levels | response to nitrogen compound | negative regulation of neuron apoptotic process | apoptotic process | system development | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of urine volume | negative regulation of phosphate metabolic process | regulation of synaptic transmission, cholinergic | astrocyte activation | multicellular organism development | negative regulation of catalytic activity | regulation of synaptic transmission, GABAergic | regulation of synaptic transmission, glutamatergic | regulation of peptidase activity | phosphorus metabolic process | response to purine-containing compound | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | positive regulation of glutamate secretion | adenylate cyclase-activating G-protein coupled receptor signaling pathway | regulation of catalytic activity | cyclic nucleotide metabolic process | regulation of phosphorylation | regulation of hormone levels | regulation of hormone secretion | negative regulation of peptidase activity | wound healing | regulation of T cell activation | regulation of gene expression | regulation of postsynaptic membrane potential | positive regulation of secretion | nervous system process | synaptic signaling | organophosphate metabolic process | regulation of lymphocyte activation | regulation of nitrogen compound metabolic process | negative regulation of T cell activation | regulation of cysteine-type endopeptidase activity involved in apoptotic process | small molecule metabolic process | regulation of vascular permeability | vesicle-mediated transport | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | nucleobase-containing small molecule metabolic process | second-messenger-mediated signaling | synaptic transmission, glutamatergic | biosynthetic process | locomotory behavior | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | eating behavior | glial cell differentiation | purine ribonucleotide biosynthetic process | startle response | response to toxic substance | regulation of glutamate secretion | regulation of apoptotic signaling pathway | response to xenobiotic stimulus | regulation of circadian sleep/wake cycle, sleep | phosphate-containing compound metabolic process | negative regulation of cell-cell adhesion | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of response to drug | regulation of neuron apoptotic process | negative regulation of cell activation | inflammatory response | astrocyte differentiation | cyclic-nucleotide-mediated signaling | regulation of protein metabolic process | positive regulation of signal transduction | positive regulation of establishment of protein localization | regulation of protein phosphorylation | protein kinase C-activating G-protein coupled receptor signaling pathway | regulation of locomotion | regulation of RNA metabolic process | positive regulation of synaptic transmission, GABAergic | regulation of tube size | positive regulation of transport | coagulation | neuron differentiation | cAMP metabolic process | protein metabolic process | inhibitory postsynaptic potential | regulation of establishment of protein localization | response to organic substance | cAMP-mediated signaling | regulation of kinase activity | response to wounding | import into cell | anatomical structure development | response to amine | cell surface receptor signaling pathway | vasodilation | cell projection organization | metabolic process | regulation of RNA biosynthetic process | regulation of body fluid levels | negative regulation of programmed cell death | regulation of tube diameter | endocytosis | regulation of secretion | behavior | positive regulation of cell death | membrane depolarization | nucleobase-containing compound metabolic process | neuron projection development | response to caffeine | organic substance metabolic process | cell death | adenosine receptor signaling pathway | positive regulation of amino acid transport | positive regulation of ion transport | negative regulation of cellular protein metabolic process | regulation of cell activation | regulation of protein secretion | positive regulation of programmed cell death | regulation of phosphate metabolic process | response to alkaloid | renal system process | negative regulation of vascular permeability | positive regulation of synaptic transmission, cholinergic | positive regulation of organic acid transport | cell activation | positive regulation of protein transport | negative regulation of protein metabolic process | sensory perception | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | regulation of cell communication | negative regulation of molecular function | signaling | feeding behavior | regulation of transcription, DNA-templated | glial cell development | response to organic cyclic compound | ribose phosphate biosynthetic process | neuromuscular process | cell development | cellular protein metabolic process | anatomical structure morphogenesis | regulation of endopeptidase activity | regulation of circadian rhythm | regulation of ion transport | developmental process | positive regulation of anion transport | regulation of calcium ion transport | negative regulation of alpha-beta T cell activation | carbohydrate derivative metabolic process | regulation of transport | synaptic transmission, cholinergic | negative regulation of cell proliferation | regulation of cell-cell adhesion | cellular defense response | response to organonitrogen compound | heterocycle metabolic process | negative regulation of hydrolase activity | regulation of anion transport | central nervous system development | regulation of synaptic plasticity | response to amphetamine | G-protein coupled adenosine receptor activity | cellular metabolic process | regulation of protein localization | regulation of cell death | positive regulation of circadian sleep/wake cycle, sleep | negative regulation of cell death | positive regulation of blood vessel diameter | regulation of inflammatory response | negative regulation of locomotion | phagocytosis | positive regulation of apoptotic signaling pathway | positive regulation of signaling | signal transduction | regulation of signaling | negative regulation of endopeptidase activity | regulation of neurotransmitter secretion | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
presynaptic membrane | intermediate filament | supramolecular fiber | integral component of membrane | dendrite | synapse | neuron projection | axolemma | somatodendritic compartment | integral component of presynaptic membrane | cell projection membrane | cell body | cell | neuronal cell body | intrinsic component of membrane | synaptic membrane | intracellular organelle | dendritic tree | intermediate filament cytoskeleton | leading edge membrane | main axon | presynapse | cell projection | postsynaptic membrane | endomembrane system | postsynapse | plasma membrane | cell leading edge | postsynaptic density | asymmetric synapse | integral component of postsynaptic membrane | integral component of plasma membrane | organelle | postsynaptic specialization | presynaptic active zone | cell periphery | axon | cytoskeleton | intracellular | membrane | supramolecular complex | neuron projection membrane | intrinsic component of plasma membrane
