QuickView for ADRA2C (gene)

Gene Symbol:

ADRA2C Homo sapiens

Full name:

adrenoceptor alpha 2C

Synonyms:

ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2CAR, alpha-2C adrenergic receptor, adrenergic, alpha-2C-, receptor, alpha-2 adrenergic receptor subtype C4, alpha-2C adrenoceptor, alpha-2C adrenoreceptor, alpha-2CAR, alpha2-AR-C4

Genomic Location:

Chr 4: 3738094-3740051

Description:

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed th...

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Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGANTCA_AP1_C ,  VDR_Q3 ,  GCANCTGNY_MYOD_Q6 ,  AP2ALPHA_01 ,  WHN_B ,  CTTTGTA_MIR524 ,  CACCCBINDINGFACTOR_Q6 ,  TTCYRGAA_UNKNOWN ,  AP2_Q3 ,  TTGCCAA_MIR182 ,  PAX_Q6 ,  CAGCTG_AP4_Q5 ,  ZF5_B ,  TCF1P_Q6 ,  LMO2COM_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-182

Cytogenetic Map:

4p16.3

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