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QuickView for ADRB1 (gene)


Gene Symbol:
ADRB1 Homo sapiens Homo sapiens
Full name:
adrenoceptor beta 1
Synonyms:
ADRB1R, B1AR, BETA1AR, RHR, beta-1 adrenergic receptor, adrenergic, beta-1-, receptor, beta-1 adrenoceptor, beta-1 adrenoreceptor
Genomic Location:
Chr 10: 115793796-115796657
Description:
The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 10
10q25.3


Transcripts Names
NM_000684
Protein Names
B0LPE2
Q5T5Y4
Q9UKG8
Q9UKG7
P08588



GO Molecular Function

guanyl-nucleotide exchange factor activity | GTPase binding | epinephrine binding | transmembrane signaling receptor activity | enzyme binding | beta-adrenergic receptor activity | G-protein coupled receptor activity | signaling receptor binding | beta1-adrenergic receptor activity | G-protein coupled amine receptor activity | Ras GTPase binding | adrenergic receptor binding | molecular function regulator | protein domain specific binding | adrenergic receptor activity | signaling receptor activity | protein heterodimerization activity | alpha-2A adrenergic receptor binding | organic cyclic compound binding | protein binding | protein dimerization activity | G-protein coupled receptor binding | Ras guanyl-nucleotide exchange factor activity | norepinephrine binding | small GTPase binding | PDZ domain binding

GO Biological Process

positive regulation of heart contraction | response to extracellular stimulus | regulation of blood vessel diameter | response to nutrient levels | positive regulation of blood circulation | guanyl-nucleotide exchange factor activity | intracellular signal transduction | regulation of the force of heart contraction by chemical signal | cell differentiation | regulation of systemic arterial blood pressure by norepinephrine-epinephrine | adaptive thermogenesis | positive regulation of GTPase activity | cellular process | negative regulation of developmental growth | diet induced thermogenesis | positive regulation of catalytic activity | regulation of multicellular organism growth | brown fat cell differentiation | regulation of cellular process | regulation of metabolic process | regulation of systemic arterial blood pressure mediated by a chemical signal | beta-adrenergic receptor activity | G-protein coupled receptor activity | response to stimulus | positive regulation of blood pressure | positive regulation of cold-induced thermogenesis | regulation of blood vessel size | response to cold | response to stress | beta1-adrenergic receptor activity | adenylate cyclase-activating adrenergic receptor signaling pathway | multicellular organismal homeostasis | regulation of blood circulation | G-protein coupled amine receptor activity | regulation of heart rate | response to temperature stimulus | positive regulation of the force of heart contraction by chemical signal | blood circulation | G-protein coupled receptor signaling pathway | molecular function regulator | negative regulation of blood pressure | adrenergic receptor activity | regulation of signal transduction | negative regulation of growth | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | adenylate cyclase-activating G-protein coupled receptor signaling pathway | regulation of catalytic activity | regulation of blood pressure | regulation of systemic arterial blood pressure | positive regulation of intracellular signal transduction | fat cell differentiation | regulation of the force of heart contraction | positive regulation of hydrolase activity | second-messenger-mediated signaling | negative regulation of multicellular organism growth | regulation of GTPase activity | regulation of heart contraction | cell communication | cyclic-nucleotide-mediated signaling | positive regulation of signal transduction | regulation of cAMP-mediated signaling | homeostatic process | regulation of tube size | positive regulation of the force of heart contraction by epinephrine-norepinephrine | positive regulation of molecular function | positive regulation of heart rate | activation of adenylate cyclase activity | multicellular organismal response to stress | fear response | regulation of growth | cAMP-mediated signaling | regulation of intracellular signal transduction | vasodilation | metabolic process | regulation of tube diameter | Ras guanyl-nucleotide exchange factor activity | positive regulation of cAMP-mediated signaling | temperature homeostasis | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | regulation of cell communication | signaling | negative regulation of systemic arterial blood pressure | regulation of developmental growth | regulation of developmental process | developmental process | norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure | positive regulation of heart rate by epinephrine-norepinephrine | adrenergic receptor signaling pathway | heat generation | response to dietary excess | positive regulation of metabolic process | positive regulation of blood vessel diameter | positive regulation of signaling | signal transduction | regulation of signaling | multicellular organismal process

GO Cellular Component

integral component of membrane | cytoplasmic vesicle | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | endomembrane system | plasma membrane | vesicle | integral component of plasma membrane | endosome | membrane-bounded organelle | organelle | cell periphery | early endosome | intracellular vesicle | intracellular | membrane | intrinsic component of plasma membrane