QuickView for AFG3L2 (gene)

Gene Symbol:

AFG3L2 Homo sapiens

Full name:

AFG3 like matrix AAA peptidase subunit 2

Synonyms:

SCA28, SPAX5, AFG3-like protein 2, AFG3 ATPase family gene 3-like 2, AFG3 ATPase family member 3-like 2, AFG3 like AAA ATPase 2, ATPase family gene 3, yeast, paraplegin-like protein

Genomic Location:

Chr 18: 12319108-12367194

Description:

This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. This gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders.

This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. This gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGACCTY_ERR1_Q2 ,  RORA1_01 ,  ERR1_Q2 ,  TGACCTTG_SF1_Q6 ,  SF1_Q6

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-27

Cytogenetic Map:

18p11.21

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